Design, recruitment, and retention of African-American smokers in a pharmacokinetic study
© Faseru et al; licensee BioMed Central Ltd. 2010
Received: 26 August 2009
Accepted: 19 January 2010
Published: 19 January 2010
African-Americans remain underrepresented in clinical research despite experiencing a higher burden of disease compared to all other ethnic groups in the United States. The purpose of this article is to describe the study design and discuss strategies used to recruit and retain African-American smokers in a pharmacokinetic study.
The parent study was designed to evaluate the differences in the steady-state concentrations of bupropion and its three principal metabolites between African-American menthol and non-menthol cigarette smokers. Study participation consisted of four visits at a General Clinical Research Center (GCRC) over six weeks. After meeting telephone eligibility requirements, phone-eligible participants underwent additional screening during the first two GCRC visits. The last two visits (pharmacokinetic study phase) required repeated blood draws using an intravenous catheter over the course of 12 hours.
Five hundred and fifteen African-American smokers completed telephone screening; 187 were phone-eligible and 92 were scheduled for the first GCRC visit. Of the 81 who attended the first visit, 48 individuals were enrolled in the pharmacokinetic study, and a total of 40 individuals completed the study (83% retention rate).
Although recruitment of African-American smokers into a non-treatment, pharmacokinetic study poses challenges, retention is feasible. The results provide valuable information for investigators embarking on non-treatment laboratory-based studies among minority populations.
Although African-Americans experience a disproportionately high burden of disease [1, 2], they remain underrepresented in clinical research [3–5, 5–14]. Clinical research studies traditionally have included predominantly White samples and only a small percentage of minority participants. Therefore, findings of these studies have limited generalizability to African-Americans or other racial/ethnic minority populations [5, 9, 15–18]. Reasons for low levels of participation of African-Americans in research studies have included mistrust of the medical and research communities, lack of awareness of potential benefits of study programs, and barriers related to low economic status [12, 19]. While some investigators are beginning to address these barriers [20–25], recruitment and retention of African-Americans in clinical research studies remain a critical challenge .
Tobacco-related morbidity and mortality is higher among African-Americans compared to other racial/ethnic groups in the United States . However, African-Americans remain underrepresented in smoking cessation and tobacco research . While about 80% of African-American smokers smoke menthol cigarettes [29–31], smoking menthol cigarettes is associated with decreased abstinence following bupropion treatment in African-American smokers [32, 33]. The purpose of the parent study was to evaluate the differences in the steady-state concentrations of bupropion and its three principal metabolites between African-American menthol and non-menthol cigarette smokers. Understanding the effect of menthol on bupropion metabolism could inform the choice of smoking cessation medications to African-American smokers. This study is unique and presents recruitment and retention challenges for the following reasons: 1) unlike clinical trials, this study was laboratory-based and involved a non-treatment-seeking study population; 2) participants were neither required to be interested in quitting nor motivated to quit; 3) participants were not in need of clinical investigation or treatment for any physical illness that would motivate them to visit the hospital multiple times and stay in the hospital for long hours of investigation. This article describes the design, successful recruitment and retention of African-Americans in our pharmacokinetic study. We will discuss challenges and solutions regarding recruitment and retention issues in the study, which could provide useful information for investigators embarking on similar research among minority populations.
The study protocol was reviewed and approved by the University of Kansas Medical Center Human Subjects Committee. This study was conducted within the General Clinical Research Center (GCRC) at the University of Kansas Medical Center.
Participants were recruited using clinic-based and community-based strategies. Clinic-based strategies included informing medical center staff about the study through flyers, broadcast emails, departmental meetings, and employee newsletters. Posters and flyers were distributed at a community health center that serves a predominantly African-American patient population. Invitation letters were sent to former research participants who gave written consent to be contacted in the future. Community strategies included paid advertisements in neighborhood newspapers, the major city paper, and on two radio stations with large African-American audiences. Research staff provided flyers to African-American business owners and religious organizations. Those interested in the study were asked to call the study office and speak with a study coordinator who assessed their eligibility for the study.
Eligible individuals identified themselves as African-American or Black, aged 18 years or older. They smoked at least 10 cigarettes per day and had a BMI between 18 and 45 kg/m2. Additionally, each participant must have smoked either mentholated or non-mentholated cigarettes exclusively for the past year. Consistent with contraindications for bupropion use, exclusion criteria included predisposition to seizures, a diagnosis of bulimia or anorexia nervosa in the past year, an unstable medical or psychiatric illness, alcohol dependency within the last year, or a myocardial infarction in the last month. In addition, individuals who planned to move from the metropolitan area in the next month, or who had used other forms of tobacco in the past 30 days, or had used bupropion in the past 30 days were excluded from participation, as were those currently using any prescription or other medications contraindicated or with known interaction with bupropion, those reporting illicit drug use and women who were pregnant, breastfeeding, or contemplating pregnancy in the next month.
Eligibility screening was multi-staged: telephone eligibility screening was followed by medical screening, and then, lastly, by screening for adverse events with medication and adherence to medication.
Study staff specifically informed callers that this was a "non-treatment study to find out how the body breaks down a medication called Zyban". Research staff verified individuals' willingness to adhere to study instructions. Interested individuals were screened on the phone according to the eligibility criteria described above. Those eligible were informed that medical screening would include an additional medical history, a physical examination and laboratory tests to rule out contraindications to bupropion use. They were instructed to fast overnight prior to the medical screening visit. A written copy of these instructions was mailed to all individuals who had passed the telephone screening.
Phone-eligible individuals came to the General Clinical Research Center (GCRC) after an overnight fast. The study staff discussed the details of the study with participants during the informed consent process. Individuals signed a written informed consent form. They provided a 20 ml blood sample for a complete blood count, a complete metabolic profile, and cotinine analysis. Women also gave a urine sample for a pregnancy test. The GCRC nurse took a medical history and examined the participants. Participants completed a baseline smoking history questionnaire and also completed a smoking topography using a CreSSmicro smoking topography device (Plowshare Technologies, Baltimore, MD). The study staff and the study physician reviewed the results of the laboratory tests, medical history and physical examination findings to determine eligibility. Eligible participants were given a sterile container for collecting urine beginning 24 hours prior to the next visit to verify their menthol status. They were also given a special cigarette carrying container (Smartpak) to use during the study.
Reporting adverse events and verifying medication adherence
Medically eligible participants were given a 7-10 day supply of placebo in a container with a Medication Event Monitoring System (MEMS) cap, an adherence verification device (AARDEX, Union City, CA). On their second visit, participants were asked about adverse events using the Common Terminology Criteria for Adverse Events, version 3.0 (National Cancer Institute). Unused study medication was collected and counted, and data were downloaded from the MEMS cap. Individuals who did not tolerate the placebo medication or used less than 75% of the prescribed dose were excluded from continued participation. Such individuals were excluded with the rationale that they were unlikely to take the active medication as prescribed during the entire study. Participants were enrolled in the pharmacokinetics phase of the study after they passed the medical adherence eligibility screening (Visit 2), and were scheduled for Visit 3. The participants continued to use the MEMS cap for the entire study to monitor bupropion use. The study staff instructed participants to bring their MEMS cap and all medications to each GCRC visit.
Pharmacokinetic Study Phase
After a seven-day placebo run-in period and an initial three-day dosing period of 150 mg/day, participants were given 300 mg/day (150 mg 2×/day) sustained-release bupropion for 20-25 days. Participants were asked to smoke their usual brand of cigarettes ad lib for the first 10-15 days (smoking condition) and to quit smoking for the remaining 10-15 days of the study (non-smoking condition). Blood samples were drawn for pharmacokinetics (PK) analysis on two occasions, 10-15 days after the commencement of bupropion while participants were still smoking (PK 1), and again at days 20-25 (PK 2) when they were required not to smoke (non-smoking condition). The blood samples at Visit 3 (PK 1) provided PK parameters when participants were exposed to both bupropion and menthol in cigarettes. Samples at Visit 4 (PK 2) provided PK parameters when participants were exposed only to bupropion but not to menthol. At each PK visit, approximately 10 ml of blood specimens for PK were taken through an intravenous line inserted into the participant's arm prior to ingestion of 150 mg bupropion-SR and at 1, 2, 2.5, 3, 3.5, 4, 5, 6, 8, and 12 hours after ingestion of the first dose of 150 mg bupropion-SR. Use of the second dose of bupropion for the day was delayed until after all blood draws were completed.
Once participants were scheduled for visits, reminder letters were mailed one week before each visit, and reminder telephone calls were placed two days and one day before each visit. The study staff provided information about the procedures that participants would undergo in the upcoming visit and answered questions. Participants who missed an appointment were contacted by telephone to reschedule the appointment, provided they were still within the study visit window. The research team met weekly to review recruitment and retention progress and to provide feedback to the study staff.
Monetary compensation was discussed with participants during the informed consent process. Participants were given $50 Visa gift cards for each screening visit and $150 Visa gift cards for each pharmacokinetic study visit. Fifty dollar Visa gift cards were given to the participants for the use of Smartpak and MEMS devices. Additional $50 Visa gift cards were given to participants who were able to abstain from smoking during the non-smoking phase (verified with Nic check).
This is a descriptive summary and, as such, we summarized categorical variables by frequencies and percentages and continuous variables by means and standard deviations using SAS statistical package, version 9.1.
Baseline characteristics of participants enrolled in the PK study (n = 48)
Menthol (n = 29)
Non-Menthol (n = 19)
Mean age (SD)
Gender, n (% female)
Mean age of smoking initiation
Mean age of regular smoking
No. of years smoked
Mean CPD at baseline
This study demonstrated that African-American smokers can be successfully recruited to participate in an intensive GCRC-based non-treatment study. Given the intensity of participation required for the study, including 24-hour urine collection, the use of cigarette and pill monitoring devices, the number and duration of study visits, and multiple blood draws, achieving this recruitment level was considered a success. This outcome supports the feasibility of including African-Americans in laboratory-based research. Showing that African-Americans will volunteer to enroll in this type of research is important, given the persistent national problem of underrepresentation of African-Americans in clinical studies . The recruitment goal of the study was to have 40 African-Americans complete the pharmacokinetic study. We screened 515 and identified 187 eligible African-American smokers. Of 81 individuals scheduled for the medical screening (Visit 1) at the GCRC, 49.4% completed the full PK study. It should be noted that it took approximately 12 months to meet this enrollment goal, a much longer time than is needed to recruit the same number of smokers in most smoking cessation studies [34–36]. This discrepancy is likely due to the intensive nature of the protocol as well as the location of the study. This study was located in an academic medical center and most of our participants heard about the study through newspaper advertisement. This is a departure from our previous study in a community health center serving a predominantly low-income African-American population. In that study, word of mouth yielded more participants . Our advertisement strategies also played a role. Periodically, we reviewed progress with recruitment methods and invested more in newspaper advertisement, which proved to be more effective compared to other sources.
Multiple factors contributed to recruitment success. Our research team has a track record of successfully engaging African-Americans in research studies, and we applied this experience to our recruitment efforts [32, 34, 37–53]. We emphasized cultural competence and cultural sensitivity training within our research team. We involved the African-American community and health care providers through a Community Advisory Board in the planning and execution of our projects . Our efforts in the community have progressively built trust, which is critical given that lack of trust is a major impediment to the participation of African-Americans in medical research studies . We integrated recruitment tracking mechanisms to maximize retention of our participants. In this study, we achieved a relatively high retention rate of 83%. Of the 48 participants who met final eligibility criteria and enrolled in the pharmacokinetic study, 40 participants completed the study. This rate is similar to the retention rates of 84% we obtained in our previous clinical trials [52, 54], but lower than 90%, reported in a more intensive long-term clinical trial involving African-Americans with renal insufficiency . This implies that retention might be better in a treatment-seeking population than in a non-treatment-seeking population.
The recruitment of African-American non-menthol smokers into our study was particularly challenging. Only about 20% of African-American smokers smoke non-menthol cigarettes [29–32, 56]. Because of the lower prevalence of African-American non-menthol smokers, we could not enroll eligible menthol smokers until we found non-menthol smokers who could be matched with menthol smokers. Consequently, we had a long waiting list of menthol smokers who, although eligible for the study, could not be enrolled due to lack of a non-menthol match. This sampling technique is prone to selection bias and may limit the generalization of our study findings. This limitation speaks to methodological challenges pertaining to research involving menthol and non-menthol African-American smokers.
The majority of the participants who were excluded from this study after the informed consent process either did not adhere to medication regimen or did not keep the scheduled appointment. We do not know if failure to attend visit during the abstinence phase was due to the fact that some of the smokers could not stop smoking during this phase. While the exclusion criteria were carefully chosen to remove individuals who seemed unlikely to comply with our protocol, this study also provided insight into issues that warrant further investigation, such as adherence to medication among minority populations, and factors that influence minority participants to not keep the study appointments. Illicit drug use (primarily marijuana) accounted for 19.5% of those who were excluded from study after consenting to participate. Although use of illicit drugs was a clear exclusion criterion, we administered this question in person because of its sensitive nature and the need to get more accurate information along with a certificate of confidentiality on their behalf from the federal government agency for their protection.
Our study demonstrates the feasibility of recruiting African-American smokers to a pharmacokinetic study, and identifies unique challenges to recruitment and retention. These challenges include intense eligibility criteria with multiple levels of eligibility, rigorous protocol, and invasive procedures. Despite these, we have demonstrated that recruiting African-Americans in non-treatment studies involving multiple blood draws and follow-up visits can be accomplished effectively. This paper provides valuable information for investigators embarking on non-treatment laboratory-based studies among minority populations.
The authors would like to thank Michelle Boyd, Qingjiang Hou, Tricia Snow, Dawn Dillinger, Diana Stewart, Jean Sunega, and the KUMC GCRC Staff for their efforts on this project. We are grateful to the volunteers who participated in this study. This work was performed at the University of Kansas Medical Center, Kansas City, Kansas, with support from the National Institute on Drug Abuse (R21 DA 018720) and National Cancer Institute (R01 CA091912). KUMC GCRC is funded by the National Center for Research Resources (M01 RR0239410). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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