This article quotes me as saying (in reference 13) that the Law & Kaldor method is likely to be biased towards the null. But in fact reference 13 illustrates a far worse situation: data were simulated with no treatment effect, yet the Law & Kaldor method estimated an "adjusted" hazard ratio of 1.48 (95% CI 1.44 to 1.52). By contrast, methods based on a structural model have the highly desirable property of being unbiased under the null.
Law & Kaldor method
25 March 2011
This article quotes me as saying (in reference 13) that the Law & Kaldor method is likely to be biased towards the null. But in fact reference 13 illustrates a far worse situation: data were simulated with no treatment effect, yet the Law & Kaldor method estimated an "adjusted" hazard ratio of 1.48 (95% CI 1.44 to 1.52). By contrast, methods based on a structural model have the highly desirable property of being unbiased under the null.
Competing interests
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