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Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

  • Benjamin Kasenda1,
  • Erik B von Elm2, 3,
  • John You4, 5,
  • Anette Blümle3,
  • Yuki Tomonaga6,
  • Ramon Saccilotto1,
  • Alain Amstutz1,
  • Theresa Bengough2,
  • Jörg Meerpohl3,
  • Mihaela Stegert1,
  • Kari A O Tikkinen4, 7,
  • Ignacio Neumann4,
  • Alonso Carrasco-Labra4,
  • Markus Faulhaber4,
  • Sohail Mulla4,
  • Dominik Mertz4,
  • Elie A Akl4, 8,
  • Dirk Bassler9,
  • Jason W Busse4, 10,
  • Ignacio Ferreira-González11,
  • Francois Lamontagne12,
  • Alain Nordmann1,
  • Rachel Rosenthal13,
  • Stefan Schandelmaier14,
  • Xin Sun15,
  • Per O Vandvik16,
  • Bradley C Johnston17,
  • Martin A Walter18,
  • Bernard Burnand2,
  • Matthias Schwenkglenks6,
  • Heiner C Bucher1,
  • Gordon H Guyatt4 and
  • Matthias Briel1, 4Email author
Contributed equally
BMC Medical Research Methodology201212:131

DOI: 10.1186/1471-2288-12-131

Received: 23 July 2012

Accepted: 1 August 2012

Published: 28 August 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
23 Jul 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
31 Jul 2012 Author responded Author comments - Benjamin Kasenda
Resubmission - Version 3
31 Jul 2012 Submitted Manuscript version 3
1 Aug 2012 Editorially accepted
28 Aug 2012 Article published 10.1186/1471-2288-12-131

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel
Cochrane Switzerland, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital
German Cochrane Centre, Institute of Medical Biometry and Medical Informatics, University Medical Centre Freiburg
Department of Clinical Epidemiology and Biostatistics, McMaster University
Department of Medicine, McMaster University
Institute for Social and Preventive Medicine
Department of Urology, Helsinki University Central Hospital and University of Helsinki
Departments of Medicine and Family Medicine, State University of New York at Buffalo
Department of Neonatology and Center for Pediatric Clinical Studies, University Children’s Hospital Tübingen
Department of Anesthesia, McMaster University
Epidemiology Unit, Department of Cardiology, Vall d'Hebron Hospital and CIBER de Epidemiología y Salud Publica (CIBERESP)
Centre de Recherche Clinique Étienne-Le Bel and Department of Medicine, Université de Sherbrooke
Department of Surgery, University Hospital Basel
Academy of Swiss Insurance Medicine, University Hospital Basel
Center for Health Research, Kaiser Permanente Northwest
Norwegian Knowledge Centre for the Health Services
Department of Anesthesia & Pain Medicine, The Hospital for Sick Children
Department of Nuclear Medicine, University Hospital Bern