Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Research article

    Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

    Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. ...

    Nils Ternès, Federico Rotolo and Stefan Michiels

    BMC Medical Research Methodology 2017 17:83

    Published on: 22 May 2017

  2. Research article

    Changes in affect after completing a mailed survey about trauma: two pre- and post-test studies in former disability applicants for posttraumatic stress disorder

    One potential concern with using mailed surveys containing trauma-related content is the possibility of re-traumatizing survivors without a trained mental health professional present. Prior research provides i...

    Maureen Murdoch, Shannon Marie Kehle-Forbes and Melissa Ruth Partin

    BMC Medical Research Methodology 2017 17:81

    Published on: 10 May 2017

  3. Research Article

    On comparison of net survival curves

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Klemen Pavlič and Maja Pohar Perme

    BMC Medical Research Methodology 2017 17:79

    Published on: 2 May 2017

  4. Research article

    Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    BMC Medical Research Methodology 2017 17:78

    Published on: 28 April 2017

  5. Research article

    The effectiveness of a monetary incentive offer on survey response rates and response completeness in a longitudinal study

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    BMC Medical Research Methodology 2017 17:77

    Published on: 26 April 2017

  6. Technical advance

    Assessing the complexity of interventions within systematic reviews: development, content and use of a new tool (iCAT_SR)

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    BMC Medical Research Methodology 2017 17:76

    Published on: 26 April 2017

  7. Research article

    Assessing the impact of natural policy experiments on socioeconomic inequalities in health: how to apply commonly used quantitative analytical methods?

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    BMC Medical Research Methodology 2017 17:68

    Published on: 20 April 2017

  8. Research article

    Does the association between adherence to statin medications and mortality depend on measurement approach? A retrospective cohort study

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    BMC Medical Research Methodology 2017 17:66

    Published on: 20 April 2017

  9. Research article

    Kappa statistic to measure agreement beyond chance in free-response assessments

    The usual kappa statistic requires that all observations be enumerated. However, in free-response assessments, only positive (or abnormal) findings are notified, but negative (or normal) findings are not. This...

    Marc Carpentier, Christophe Combescure, Laura Merlini and Thomas V. Perneger

    BMC Medical Research Methodology 2017 17:62

    Published on: 19 April 2017

  10. Research article

    Review and evaluation of performance measures for survival prediction models in external validation settings

    When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have ...

    M. Shafiqur Rahman, Gareth Ambler, Babak Choodari-Oskooei and Rumana Z. Omar

    BMC Medical Research Methodology 2017 17:60

    Published on: 18 April 2017

  11. Research article

    Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological review of health technology assessments

    Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from vario...

    Bethany Shinkins, Yaling Yang, Lucy Abel and Thomas R. Fanshawe

    BMC Medical Research Methodology 2017 17:56

    Published on: 14 April 2017

  12. Research Article

    Comparison of surveillance-based metrics for the assessment and monitoring of disease detection: simulation study about type 2 diabetes

    Screening and detection of cases are a common public health priority for treatable chronic conditions with long subclinical periods. However, the validity of commonly-used metrics from surveillance systems for...

    Ralph Brinks, Annika Hoyer, Deborah B. Rolka, Oliver Kuss and Edward W. Gregg

    BMC Medical Research Methodology 2017 17:54

    Published on: 11 April 2017

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