Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Research article

    Incorporating nonlinearity into mediation analyses

    Mediation is an important issue considered in the behavioral, medical, and social sciences. It addresses situations where the effect of a predictor variable X on an outcome variable Y is explained to some extent ...

    George J. Knafl, Kathleen A. Knafl, Margaret Grey, Jane Dixon, Janet A. Deatrick and Agatha M. Gallo

    BMC Medical Research Methodology 2017 17:45

    Published on: 21 March 2017

  2. Research article

    Standardizing effect size from linear regression models with log-transformed variables for meta-analysis

    Meta-analysis is very useful to summarize the effect of a treatment or a risk factor for a given disease. Often studies report results based on log-transformed variables in order to achieve the principal assum...

    Miguel Rodríguez-Barranco, Aurelio Tobías, Daniel Redondo, Elena Molina-Portillo and María José Sánchez

    BMC Medical Research Methodology 2017 17:44

    Published on: 17 March 2017

  3. Research article

    Trial Sequential Analysis in systematic reviews with meta-analysis

    Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded...

    Jørn Wetterslev, Janus Christian Jakobsen and Christian Gluud

    BMC Medical Research Methodology 2017 17:39

    Published on: 6 March 2017

  4. Research article

    A systematic review of studies with a representative sample of refugees and asylum seekers living in the community for participation in mental health research

    The aim was to review the literature to identify the most effective methods for creating a representative sample of refugee and asylum seeker groups living in the community to participate in health and mental ...

    Joanne C. Enticott, Frances Shawyer, Shiva Vasi, Kimberly Buck, I-Hao Cheng, Grant Russell, Ritsuko Kakuma, Harry Minas and Graham Meadows

    BMC Medical Research Methodology 2017 17:37

    Published on: 2 March 2017

  5. Research article

    Estimation of treatment preference effects in clinical trials when some participants are indifferent to treatment choice

    In the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual ...

    Stephen D. Walter, Robin M. Turner, Petra Macaskill, Kirsten J. McCaffery and Les Irwig

    BMC Medical Research Methodology 2017 17:29

    Published on: 20 February 2017

  6. Research article

    Impact of communities, health, and emotional-related factors on smoking use: comparison of joint modeling of mean and dispersion and Bayes’ hierarchical models on add health survey

    The analysis of correlated binary data is commonly addressed through the use of conditional models with random effects included in the systematic component as opposed to generalized estimating equations (GEE) ...

    Jie Pu, Di Fang and Jeffrey R. Wilson

    BMC Medical Research Methodology 2017 17:20

    Published on: 3 February 2017

  7. Research article

    Evaluation of biases present in the cohort multiple randomised controlled trial design: a simulation study

    The cohort multiple randomised controlled trial (cmRCT) design provides an opportunity to incorporate the benefits of randomisation within clinical practice; thus reducing costs, integrating electronic healthc...

    Jane Candlish, Alexander Pate, Matthew Sperrin and Tjeerd van Staa

    BMC Medical Research Methodology 2017 17:17

    Published on: 31 January 2017

    The Erratum to this article has been published in BMC Medical Research Methodology 2017 17:47

  8. Research article

    Psychometric analysis of the brief symptom inventory 18 (BSI-18) in a representative German sample

    The BSI-18 contains the three six-item scales somatization, depression, and anxiety as well as the Global Severity Index (GSI), including all 18 items. The BSI-18 is the latest and shortest of the multidimensi...

    Gabriele Helga Franke, Susanne Jaeger, Heide Glaesmer, Claus Barkmann, Katja Petrowski and Elmar Braehler

    BMC Medical Research Methodology 2017 17:14

    Published on: 26 January 2017

  9. Research Article

    Estimating a population cumulative incidence under calendar time trends

    The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over...

    Stefan N. Hansen, Morten Overgaard, Per K. Andersen and Erik T. Parner

    BMC Medical Research Methodology 2017 17:7

    Published on: 11 January 2017

  10. Research article

    Centralising and optimising decentralised stroke care systems: a simulation study on short-term costs and effects

    Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system.

    Maarten M. H. Lahr, Durk-Jouke van der Zee, Gert-Jan Luijckx, Patrick C. A. J. Vroomen and Erik Buskens

    BMC Medical Research Methodology 2017 17:5

    Published on: 10 January 2017

  11. Research article

    G-computation of average treatment effects on the treated and the untreated

    Average treatment effects on the treated (ATT) and the untreated (ATU) are useful when there is interest in: the evaluation of the effects of treatments or interventions on those who received them, the presenc...

    Aolin Wang, Roch A. Nianogo and Onyebuchi A. Arah

    BMC Medical Research Methodology 2017 17:3

    Published on: 9 January 2017

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