Data analysis, statistics and modelling

Section edited by Chiu-Hsieh (Paul) Hsu

This section considers manuscripts that investigate how statistical techniques can impact study results along with manuscripts that propose new statistical methods that have an application in medical research.

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  1. Research article

    Estimation of treatment preference effects in clinical trials when some participants are indifferent to treatment choice

    In the two-stage randomised trial design, a randomly sampled subset of study participants are permitted to choose their own treatment, while the remaining participants are randomised to treatment in the usual ...

    Stephen D. Walter, Robin M. Turner, Petra Macaskill, Kirsten J. McCaffery and Les Irwig

    BMC Medical Research Methodology 2017 17:29

    Published on: 20 February 2017

  2. Research article

    Impact of communities, health, and emotional-related factors on smoking use: comparison of joint modeling of mean and dispersion and Bayes’ hierarchical models on add health survey

    The analysis of correlated binary data is commonly addressed through the use of conditional models with random effects included in the systematic component as opposed to generalized estimating equations (GEE) ...

    Jie Pu, Di Fang and Jeffrey R. Wilson

    BMC Medical Research Methodology 2017 17:20

    Published on: 3 February 2017

  3. Research article

    Psychometric analysis of the brief symptom inventory 18 (BSI-18) in a representative German sample

    The BSI-18 contains the three six-item scales somatization, depression, and anxiety as well as the Global Severity Index (GSI), including all 18 items. The BSI-18 is the latest and shortest of the multidimensi...

    Gabriele Helga Franke, Susanne Jaeger, Heide Glaesmer, Claus Barkmann, Katja Petrowski and Elmar Braehler

    BMC Medical Research Methodology 2017 17:14

    Published on: 26 January 2017

  4. Research Article

    Estimating a population cumulative incidence under calendar time trends

    The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over...

    Stefan N. Hansen, Morten Overgaard, Per K. Andersen and Erik T. Parner

    BMC Medical Research Methodology 2017 17:7

    Published on: 11 January 2017

  5. Research article

    Centralising and optimising decentralised stroke care systems: a simulation study on short-term costs and effects

    Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system.

    Maarten M. H. Lahr, Durk-Jouke van der Zee, Gert-Jan Luijckx, Patrick C. A. J. Vroomen and Erik Buskens

    BMC Medical Research Methodology 2017 17:5

    Published on: 10 January 2017

  6. Research article

    G-computation of average treatment effects on the treated and the untreated

    Average treatment effects on the treated (ATT) and the untreated (ATU) are useful when there is interest in: the evaluation of the effects of treatments or interventions on those who received them, the presenc...

    Aolin Wang, Roch A. Nianogo and Onyebuchi A. Arah

    BMC Medical Research Methodology 2017 17:3

    Published on: 9 January 2017

  7. Research article

    Outcome-sensitive multiple imputation: a simulation study

    Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values,...

    Evangelos Kontopantelis, Ian R. White, Matthew Sperrin and Iain Buchan

    BMC Medical Research Methodology 2017 17:2

    Published on: 9 January 2017

  8. Research article

    Clinical prediction in defined populations: a simulation study investigating when and how to aggregate existing models

    Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. An emerging alternative is to aggregate existing CP...

    Glen P. Martin, Mamas A. Mamas, Niels Peek, Iain Buchan and Matthew Sperrin

    BMC Medical Research Methodology 2017 17:1

    Published on: 6 January 2017

  9. Research article

    Application of a nonrandomized stepped wedge design to evaluate an evidence-based quality improvement intervention: a proof of concept using simulated data on patient-centered medical homes

    Stepped wedge designs have gained recognition as a method for rigorously assessing implementation of evidence-based quality improvement interventions (QIIs) across multiple healthcare sites. In theory, this de...

    Alexis K. Huynh, Martin L. Lee, Melissa M. Farmer and Lisa V. Rubenstein

    BMC Medical Research Methodology 2016 16:143

    Published on: 21 October 2016

  10. Software

    Health Equity Assessment Toolkit (HEAT): software for exploring and comparing health inequalities in countries

    It is widely recognised that the pursuit of sustainable development cannot be accomplished without addressing inequality, or observed differences between subgroups of a population. Monitoring health inequaliti...

    Ahmad Reza Hosseinpoor, Devaki Nambiar, Anne Schlotheuber, Daniel Reidpath and Zev Ross

    BMC Medical Research Methodology 2016 16:141

    Published on: 19 October 2016

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