Study design

Section edited by Timothy Beebe

This section considers manuscripts that investigate how choices of research methodology and study design can impact study results, including research participation and study outcomes.

Previous Page Page 1 of 5 Next Page
  1. Research Article

    On the censored cost-effectiveness analysis using copula information

    Information and theory beyond copula concepts are essential to understand the dependence relationship between several marginal covariates distributions. In a therapeutic trial data scheme, most of the time, ce...

    Charles Fontaine, Jean-Pierre Daurès and Paul Landais

    BMC Medical Research Methodology 2017 17:27

    Published on: 15 February 2017

  2. Research article

    Self-controlled designs in pharmacoepidemiology involving electronic healthcare databases: a systematic review

    Observational studies are widely used in pharmacoepidemiology. Several designs can be used, in particular self-controlled designs (case-crossover and self-controlled case series). These designs offer the advan...

    Nathalie Gault, Johann Castañeda-Sanabria, Yann De Rycke, Sylvie Guillo, Stéphanie Foulon and Florence Tubach

    BMC Medical Research Methodology 2017 17:25

    Published on: 8 February 2017

  3. Research article

    Testing a systematic approach to identify and prioritise barriers to successful implementation of a complex healthcare intervention

    Multiple barriers may inhibit the adoption of clinical interventions and impede successful implementation. Use of standardised methods to prioritise barriers to target when selecting implementation interventio...

    Louise E. Craig, Leonid Churilov, Liudmyla Olenko, Dominique A. Cadilhac, Rohan Grimley, Simeon Dale, Cintia Martinez-Garduno, Elizabeth McInnes, Julie Considine, Jeremy M. Grimshaw and Sandy Middleton

    BMC Medical Research Methodology 2017 17:24

    Published on: 7 February 2017

  4. Research article

    Estimating the size of the homeless adolescent population across seven cities in Cambodia

    The Government of Cambodia has committed to supporting family care for vulnerable children, including homeless populations. Collecting baseline data on the numbers and characteristics of homeless adolescents w...

    Lindsay Stark, Beth L. Rubenstein, Kimchoeun Pak, Rosemary Taing, Gary Yu, Sok Kosal and Leslie Roberts

    BMC Medical Research Methodology 2017 17:13

    Published on: 26 January 2017

  5. Research article

    Multiple triangulation and collaborative research using qualitative methods to explore decision making in pre-hospital emergency care

    Paramedics make important and increasingly complex decisions at scene about patient care. Patient safety implications of influences on decision making in the pre-hospital setting were previously under-research...

    Maxine Johnson, Rachel O’Hara, Enid Hirst, Andrew Weyman, Janette Turner, Suzanne Mason, Tom Quinn, Jane Shewan and A. Niroshan Siriwardena

    BMC Medical Research Methodology 2017 17:11

    Published on: 24 January 2017

  6. Debate

    Resuming the discussion of AMSTAR: What can (should) be made better?

    Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the mos...

    Uta Wegewitz, Beate Weikert, Alba Fishta, Anja Jacobs and Dawid Pieper

    BMC Medical Research Methodology 2016 16:111

    Published on: 26 August 2016

  7. Research article

    Adapting the nominal group technique for priority setting of evidence-practice gaps in implementation science

    There are a variety of methods for priority setting in health research but few studies have addressed how to prioritise the gaps that exist between research evidence and clinical practice. This study aimed to ...

    Nicole M. Rankin, Deborah McGregor, Phyllis N. Butow, Kate White, Jane L. Phillips, Jane M. Young, Sallie A. Pearson, Sarah York and Tim Shaw

    BMC Medical Research Methodology 2016 16:110

    Published on: 26 August 2016

  8. Research article

    A simulation study on matched case-control designs in the perspective of causal diagrams

    In observational studies, matched case-control designs are routinely conducted to improve study precision. How to select covariates for match or adjustment, however, is still a great challenge for estimating c...

    Hongkai Li, Zhongshang Yuan, Ping Su, Tingting Wang, Yuanyuan Yu, Xiaoru Sun and Fuzhong Xue

    BMC Medical Research Methodology 2016 16:102

    Published on: 20 August 2016

  9. Correspondence

    Establishing the Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CHIWOS): Operationalizing Community-based Research in a Large National Quantitative Study

    Community-based research has gained increasing recognition in health research over the last two decades. Such participatory research approaches are lauded for their ability to anchor research in lived experien...

    Mona Loutfy, Saara Greene, V. Logan Kennedy, Johanna Lewis, Jamie Thomas-Pavanel, Tracey Conway, Alexandra de Pokomandy, Nadia O’Brien, Allison Carter, Wangari Tharao, Valerie Nicholson, Kerrigan Beaver, Danièle Dubuc, Jacqueline Gahagan, Karène Proulx-Boucher, Robert S. Hogg…

    BMC Medical Research Methodology 2016 16:101

    Published on: 19 August 2016

  10. Research article

    Potential use of telephone surveys for non-communicable disease surveillance in developing countries: evidence from a national household survey in Lebanon

    Given the worldwide proliferation of cellphones, this paper examines their potential use for the surveillance of non-communicable disease (NCD) risk factors in a Middle Eastern country.

    Abla M. Sibai, Lilian A. Ghandour, Rawan Chaaban and Ali H. Mokdad

    BMC Medical Research Methodology 2016 16:64

    Published on: 31 May 2016

  11. Research article

    Cross-cultural adaptation of the drug-taking confidence questionnaire drug version for use in Brazil

    The Drug-Taking Confidence Questionnaire evaluates a drug user’s confidence in his or her ability to resist the urge to consume psychoactive substances in high-risk situations. This study’s objective was to de...

    Selene Cordeiro Vasconcelos, Everton Botelho Sougey, Iracema da Silva Frazão, Nigel Ernest Turner, Vânia Pinheiro Ramos and Murilo Duarte da Costa Lima

    BMC Medical Research Methodology 2016 16:55

    Published on: 18 May 2016

  12. Research article

    Factors relating to participation in follow-up to the 45 and up study in Aboriginal and non-Aboriginal individuals

    This study aimed to characterise the factors relating to participation in a postal follow-up study in Aboriginal and non-Aboriginal individuals, given the need to quantify potential biases from loss to follow-...

    Lina Gubhaju, Emily Banks, Rona Macniven, Grace Joshy, Bridgette J. McNamara, Adrian Bauman and Sandra J. Eades

    BMC Medical Research Methodology 2016 16:53

    Published on: 11 May 2016

  13. Research article

    Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction

    Inefficient experimental designs are common in animal-based biomedical research, wasting resources and potentially leading to unreplicable results. Here we illustrate the intrinsic statistical power of split-p...

    Michael Walker, Carole Fureix, Rupert Palme, Jonathan A. Newman, Jamie Ahloy Dallaire and Georgia Mason

    BMC Medical Research Methodology 2016 16:11

    Published on: 27 January 2016

  14. Research article

    Efficiency and effectiveness evaluation of an automated multi-country patient count cohort system

    With the increase of clinical trial costs during the last decades, the design of feasibility studies has become an essential process to reduce avoidable and costly protocol amendments. This design includes tim...

    Iñaki Soto-Rey, Benjamin Trinczek, Yannick Girardeau, Eric Zapletal, Nadir Ammour, Justin Doods, Martin Dugas and Fleur Fritz

    BMC Medical Research Methodology 2015 15:44

    Published on: 1 May 2015

Previous Page Page 1 of 5 Next Page

Can't find what you are looking for?

Articles for this section are still being added to this new-look site. In the meantime you can still view this section on our old site.