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  1. Research Article

    Estimating a population cumulative incidence under calendar time trends

    The risk of a disease or psychiatric disorder is frequently measured by the age-specific cumulative incidence. Cumulative incidence estimates are often derived in cohort studies with individuals recruited over...

    Stefan N. Hansen, Morten Overgaard, Per K. Andersen and Erik T. Parner

    BMC Medical Research Methodology 2017 17:7

    Published on: 11 January 2017

  2. Research article

    Centralising and optimising decentralised stroke care systems: a simulation study on short-term costs and effects

    Centralisation of thrombolysis may offer substantial benefits. The aim of this study was to assess short term costs and effects of centralisation of thrombolysis and optimised care in a decentralised system.

    Maarten M. H. Lahr, Durk-Jouke van der Zee, Gert-Jan Luijckx, Patrick C. A. J. Vroomen and Erik Buskens

    BMC Medical Research Methodology 2017 17:5

    Published on: 10 January 2017

  3. Research article

    G-computation of average treatment effects on the treated and the untreated

    Average treatment effects on the treated (ATT) and the untreated (ATU) are useful when there is interest in: the evaluation of the effects of treatments or interventions on those who received them, the presenc...

    Aolin Wang, Roch A. Nianogo and Onyebuchi A. Arah

    BMC Medical Research Methodology 2017 17:3

    Published on: 9 January 2017

  4. Research article

    Outcome-sensitive multiple imputation: a simulation study

    Multiple imputation is frequently used to deal with missing data in healthcare research. Although it is known that the outcome should be included in the imputation model when imputing missing covariate values,...

    Evangelos Kontopantelis, Ian R. White, Matthew Sperrin and Iain Buchan

    BMC Medical Research Methodology 2017 17:2

    Published on: 9 January 2017

  5. Research article

    Clinical prediction in defined populations: a simulation study investigating when and how to aggregate existing models

    Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. An emerging alternative is to aggregate existing CP...

    Glen P. Martin, Mamas A. Mamas, Niels Peek, Iain Buchan and Matthew Sperrin

    BMC Medical Research Methodology 2017 17:1

    Published on: 6 January 2017

  6. Research article

    Can longitudinal generalized estimating equation models distinguish network influence and homophily? An agent-based modeling approach to measurement characteristics

    Connected individuals (or nodes) in a network are more likely to be similar than two randomly selected nodes due to homophily and/or network influence. Distinguishing between these two influences is an importa...

    Kori Sauser Zachrison, Theodore J. Iwashyna, Achamyeleh Gebremariam, Meghan Hutchins and Joyce M Lee

    BMC Medical Research Methodology 2016 16:174

    Published on: 28 December 2016

  7. Research article

    Inter-rater reliability of the QuIS as an assessment of the quality of staff-inpatient interactions

    Recent studies of the quality of in-hospital care have used the Quality of Interaction Schedule (QuIS) to rate interactions observed between staff and inpatients in a variety of ward conditions. The QuIS was d...

    Ines Mesa-Eguiagaray, Dankmar Böhning, Chris McLean, Peter Griffiths, Jackie Bridges and Ruth M Pickering

    BMC Medical Research Methodology 2016 16:171

    Published on: 7 December 2016

  8. Research article

    Sexual Health questions included in the Health Behaviour in School-aged Children (HBSC) Study: an international methodological pilot investigation

    This paper describes the methodological developments of the sexual health items included in the Health Behaviour in School-aged Children (HBSC) study since their mandatory inclusion in the study in 2002. The c...

    Honor Young, András Költő, Marta Reis, Elizabeth M. Saewyc, Nathalie Moreau, Lorraine Burke, Alina Cosma, Béat Windlin, Saoirse Nic Gabhainn and Emmanuelle Godeau

    BMC Medical Research Methodology 2016 16:169

    Published on: 5 December 2016

  9. Research article

    ImpRess: an Implementation Readiness checklist developed using a systematic review of randomised controlled trials assessing cognitive stimulation for dementia

    Research reporting results of clinical trials, psychosocial or technological interventions frequently omit critical details needed to inform implementation in practice. The aim of this article is to develop an...

    Amy Streater, Aimee Spector, Elisa Aguirre, Jacki Stansfeld and Martin Orrell

    BMC Medical Research Methodology 2016 16:167

    Published on: 1 December 2016

  10. Research Article

    Recommendations for the analysis of individually randomised controlled trials with clustering in one arm – a case of continuous outcomes

    In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depe...

    Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield and Stephen J. Walters

    BMC Medical Research Methodology 2016 16:165

    Published on: 29 November 2016

  11. Research article

    Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

    Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might ...

    Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah and Sophia J. S. De Padua

    BMC Medical Research Methodology 2016 16:166

    Published on: 29 November 2016

  12. Research article

    Conducting a large, multi-site survey about patients’ views on broad consent: challenges and solutions

    As biobanks play an increasing role in the genomic research that will lead to precision medicine, input from diverse and large populations of patients in a variety of health care settings will be important in ...

    Maureen E. Smith, Saskia C. Sanderson, Kyle B. Brothers, Melanie F. Myers, Jennifer McCormick, Sharon Aufox, Martha J. Shrubsole, Nanibaá A. Garrison, Nathaniel D. Mercaldo, Jonathan S. Schildcrout, Ellen Wright Clayton, Armand H. Matheny Antommaria, Melissa Basford, Murray Brilliant, John J. Connolly, Stephanie M. Fullerton…

    BMC Medical Research Methodology 2016 16:162

    Published on: 24 November 2016

  13. Research Article

    No rationale for 1 variable per 10 events criterion for binary logistic regression analysis

    Ten events per variable (EPV) is a widely advocated minimal criterion for sample size considerations in logistic regression analysis. Of three previous simulation studies that examined this minimal EPV criteri...

    Maarten van Smeden, Joris A. H. de Groot, Karel G. M. Moons, Gary S. Collins, Douglas G. Altman, Marinus J. C. Eijkemans and Johannes B. Reitsma

    BMC Medical Research Methodology 2016 16:163

    Published on: 24 November 2016

  14. Research article

    Predictors of in-hospital mortality following major lower extremity amputations in type 2 diabetic patients using artificial neural networks

    Outcome prediction is important in the clinical decision-making process. Artificial neural networks (ANN) have been used to predict the risk of post-operative events, including survival, and are increasingly b...

    Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Roberto Lopez, Pablo Martin-Junco, Isabel Jimenez-Trujillo, Alejandro Alvaro-Meca, Miguel Angel Salinero-Fort and Rodrigo Jimenez-Garcia

    BMC Medical Research Methodology 2016 16:160

    Published on: 22 November 2016

  15. Research article

    Common data elements for secondary use of electronic health record data for clinical trial execution and serious adverse event reporting

    Data capture is one of the most expensive phases during the conduct of a clinical trial and the increasing use of electronic health records (EHR) offers significant savings to clinical research. To facilitate ...

    Philipp Bruland, Mark McGilchrist, Eric Zapletal, Dionisio Acosta, Johann Proeve, Scott Askin, Thomas Ganslandt, Justin Doods and Martin Dugas

    BMC Medical Research Methodology 2016 16:159

    Published on: 22 November 2016

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