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  1. Research Article

    Simulation of complex data structures for planning of studies with focus on biomarker comparison

    There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying ...

    Andreas Schulz, Daniela Zöller, Stefan Nickels, Manfred E. Beutel, Maria Blettner, Philipp S. Wild and Harald Binder

    BMC Medical Research Methodology 2017 17:90

    Published on: 13 June 2017

  2. Research article

    Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium

    The nested case-control study (NCC) design within a prospective cohort study is used when outcome data are available for all subjects, but the exposure of interest has not been collected, and is difficult or p...

    Long H. Ngo, Sharon K. Inouye, Richard N. Jones, Thomas G. Travison, Towia A. Libermann, Simon T. Dillon, George A. Kuchel, Sarinnapha M. Vasunilashorn, David C. Alsop and Edward R. Marcantonio

    BMC Medical Research Methodology 2017 17:88

    Published on: 6 June 2017

  3. Research Article

    A nonparametric multiple imputation approach for missing categorical data

    Incomplete categorical variables with more than two categories are common in public health data. However, most of the existing missing-data methods do not use the information from nonresponse (missingness) pro...

    Muhan Zhou, Yulei He, Mandi Yu and Chiu-Hsieh Hsu

    BMC Medical Research Methodology 2017 17:87

    Published on: 6 June 2017

  4. Research article

    Bayesian hierarchical piecewise regression models: a tool to detect trajectory divergence between groups in long-term observational studies

    Bayesian hierarchical piecewise regression (BHPR) modeling has not been previously formulated to detect and characterise the mechanism of trajectory divergence between groups of participants that have longitud...

    Marie-jeanne Buscot, Simon S. Wotherspoon, Costan G. Magnussen, Markus Juonala, Matthew A. Sabin, David P. Burgner, Terho Lehtimäki, Jorma S. A. Viikari, Nina Hutri-Kähönen, Olli T. Raitakari and Russell J. Thomson

    BMC Medical Research Methodology 2017 17:86

    Published on: 6 June 2017

  5. Research article

    Validity of self-reported weight and height: a cross-sectional study among Malaysian adolescents

    Self-reported weight and height are commonly used in lieu of direct measurements of weight and height in large epidemiological surveys due to inevitable constraints such as budget and human resource. However, ...

    C. C. Kee, K. H. Lim, M. G. Sumarni, C. H. Teh, Y. Y. Chan, M. I. Nuur Hafizah, Y. K. Cheah, E. O. Tee, Y. Ahmad Faudzi and M. Amal Nasir

    BMC Medical Research Methodology 2017 17:85

    Published on: 2 June 2017

  6. Research article

    Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice

    Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, t...

    Lewis Cooney, Yoon K. Loke, Su Golder, Jamie Kirkham, Andrea Jorgensen, Ian Sinha and Daniel Hawcutt

    BMC Medical Research Methodology 2017 17:84

    Published on: 2 June 2017

  7. Research article

    Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

    Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. ...

    Nils Ternès, Federico Rotolo and Stefan Michiels

    BMC Medical Research Methodology 2017 17:83

    Published on: 22 May 2017

  8. Research article

    Changes in affect after completing a mailed survey about trauma: two pre- and post-test studies in former disability applicants for posttraumatic stress disorder

    One potential concern with using mailed surveys containing trauma-related content is the possibility of re-traumatizing survivors without a trained mental health professional present. Prior research provides i...

    Maureen Murdoch, Shannon Marie Kehle-Forbes and Melissa Ruth Partin

    BMC Medical Research Methodology 2017 17:81

    Published on: 10 May 2017

  9. Research Article

    On comparison of net survival curves

    Relative survival analysis is a subfield of survival analysis where competing risks data are observed, but the causes of death are unknown. A first step in the analysis of such data is usually the estimation o...

    Klemen Pavlič and Maja Pohar Perme

    BMC Medical Research Methodology 2017 17:79

    Published on: 2 May 2017

  10. Research article

    Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance

    Double-adjustment can be used to remove confounding if imbalance exists after propensity score (PS) matching. However, it is not always possible to include all covariates in adjustment. We aimed to find the op...

    Tri-Long Nguyen, Gary S. Collins, Jessica Spence, Jean-Pierre Daurès, P. J. Devereaux, Paul Landais and Yannick Le Manach

    BMC Medical Research Methodology 2017 17:78

    Published on: 28 April 2017

  11. Research article

    Sample size and power determination when limited preliminary information is available

    We describe a novel strategy for power and sample size determination developed for studies utilizing investigational technologies with limited available preliminary data, specifically of imaging biomarkers. We...

    Christine E. McLaren, Wen-Pin Chen, Thomas D. O’Sullivan, Daniel L. Gillen, Min-Ying Su, Jeon H. Chen and Bruce J. Tromberg

    BMC Medical Research Methodology 2017 17:75

    Published on: 26 April 2017

  12. Research article

    The effectiveness of a monetary incentive offer on survey response rates and response completeness in a longitudinal study

    Achieving adequate response rates is an ongoing challenge for longitudinal studies. The World Trade Center Health Registry is a longitudinal health study that periodically surveys a cohort of ~71,000 people ex...

    Shengchao Yu, Howard E. Alper, Angela-Maithy Nguyen, Robert M. Brackbill, Lennon Turner, Deborah J. Walker, Carey B. Maslow and Kimberly C. Zweig

    BMC Medical Research Methodology 2017 17:77

    Published on: 26 April 2017

  13. Research article

    An experimental comparison of web-push vs. paper-only survey procedures for conducting an in-depth health survey of military spouses

    Previous research has found that a “web-push” approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later ...

    Hope Seib McMaster, Cynthia A. LeardMann, Steven Speigle and Don A. Dillman

    BMC Medical Research Methodology 2017 17:73

    Published on: 26 April 2017

  14. Technical advance

    Assessing the complexity of interventions within systematic reviews: development, content and use of a new tool (iCAT_SR)

    Health interventions fall along a spectrum from simple to more complex. There is wide interest in methods for reviewing ‘complex interventions’, but few transparent approaches for assessing intervention comple...

    Simon Lewin, Maggie Hendry, Jackie Chandler, Andrew D. Oxman, Susan Michie, Sasha Shepperd, Barnaby C. Reeves, Peter Tugwell, Karin Hannes, Eva A. Rehfuess, Vivien Welch, Joanne E. Mckenzie, Belinda Burford, Jennifer Petkovic, Laurie M. Anderson, Janet Harris…

    BMC Medical Research Methodology 2017 17:76

    Published on: 26 April 2017

  15. Research article

    Measurement properties of the Danish version of the Awareness and Beliefs about Cancer (ABC) measure

    The International Cancer Benchmarking Partnership aims to study international differences in cancer survival and the possible causes. Participating countries are Australia, Canada, Norway, Sweden, Denmark and ...

    Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Anders Helles Carlsen and Peter Vedsted

    BMC Medical Research Methodology 2017 17:74

    Published on: 26 April 2017

  16. Research article

    Assessing the impact of natural policy experiments on socioeconomic inequalities in health: how to apply commonly used quantitative analytical methods?

    The scientific evidence-base for policies to tackle health inequalities is limited. Natural policy experiments (NPE) have drawn increasing attention as a means to evaluating the effects of policies on health. ...

    Yannan Hu, Frank J. van Lenthe, Rasmus Hoffmann, Karen van Hedel and Johan P. Mackenbach

    BMC Medical Research Methodology 2017 17:68

    Published on: 20 April 2017

  17. Research article

    Does the association between adherence to statin medications and mortality depend on measurement approach? A retrospective cohort study

    The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures).

    Mhd. Wasem Alsabbagh, Dean Eurich, Lisa M. Lix, Thomas W. Wilson and David F. Blackburn

    BMC Medical Research Methodology 2017 17:66

    Published on: 20 April 2017

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