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Table 1 Summary results for efficacy of paracetamol/codeine combinations from randomised, double-blind, placebo-controlled trials in acute pain

From: Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg

   At least 50% pain relief At least 50% pain   
   with paracetamol and relief with placebo   
   codeine     
Paracetamol + Number of Number Percent Number Percent Relative benefit NNT (95% CI)
codeine dose trials /total (95%CI) /total (95%CI) (95% CI)  
1000 mg + 60 mg 3 65/114 57 (48-66) 9/83 11(4-18) 4.8 (2.6 to 8.8) 2.2 (1.7 to 2.9)
600/650 mg + 60 mg 13 191/398 48 (43-53) 78/418 19 (15-22) 2.5 (2.0 to 3.1) 3.4 (2.8 to 4.3)
300 mg + 30 mg 4 56/215 26 (20-32) 14/164 9 (4-13) 3.2 (1.8 to 5.6) 5.6 (4.0 to 9.8)
  1. For inclusion there had to be at least two studies.