Table 1 Summary results for efficacy of paracetamol/codeine combinations from randomised, double-blind, placebo-controlled trials in acute pain
From: Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg
| Â | Â | At least 50% pain relief | At least 50% pain | Â | Â | ||
|---|---|---|---|---|---|---|---|
| Â | Â | with paracetamol and | relief with placebo | Â | Â | ||
| Â | Â | codeine | Â | Â | Â | Â | |
Paracetamol + | Number of | Number | Percent | Number | Percent | Relative benefit | NNT (95% CI) |
codeine dose | trials | /total | (95%CI) | /total | (95%CI) | (95% CI) | Â |
1000 mg + 60 mg | 3 | 65/114 | 57 (48-66) | 9/83 | 11(4-18) | 4.8 (2.6 to 8.8) | 2.2 (1.7 to 2.9) |
600/650 mg + 60 mg | 13 | 191/398 | 48 (43-53) | 78/418 | 19 (15-22) | 2.5 (2.0 to 3.1) | 3.4 (2.8 to 4.3) |
300 mg + 30 mg | 4 | 56/215 | 26 (20-32) | 14/164 | 9 (4-13) | 3.2 (1.8 to 5.6) | 5.6 (4.0 to 9.8) |