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Table 2 Summary results for efficacy of paracetamol/codeine combinations and active comparators in randomised, double-blind, active- and placebo-controlled trials in acute pain

From: Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg

Drug/dose Number of Patients with at Percentage
  trials least 50% pain (95%CI)
   relief/total  
Paracetamol 300 mg + codeine 30 mg 3 67/272 25 (20 to 30)
Codeine 60 mg 3 24/72 33 (22 to 44)
Ibuprofen 400 mg 2 28/72 39 (28 to 50)
Paracetanol 600/650 mg 10 135/311 43 (38 to 49)
Paracetamol 1000 mg 4 64/151 42 (35 to 50)
Paracetamol 600 mg + codeine 60 mg 13 191/398 48 (43 to 53)
Diflusinal 500 mg 3 54/90 60 (50 to 70)
Ketorolac 10 mg 3 75/117 64 (55 to 73)
Diflusinal 1000 mg 3 61/92 66 (57 to 76)
Paracetamol 1000 mg + codeine 60 mg 6 150/229 66 (59 to 72)
Flurbiprofen 50 mg 3 69/99 70 (61 to 79)
Flurbiprofen 100 mg 3 70/92 76 (67 to 85)