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Table 1 Comparison of Several Methods of Evaluating a Medical Intervention

From: The Paired Availability Design for Historical Controls

Method Strengths Weaknesses
Randomized controlled trial 1. No temporal bias 1. Cost and effort
  2. No selection bias 2. Recruitment
Observational cohort study 1. No temporal bias 1. Cost of data collection
    2. Selection bias if an
     important risk factor is
     omitted or not
     adequately quantified
Paired availability design 1. Lessens selection bias 1. Assumptions in Table 2