Table 1 Characteristics of studies included in the analyses
Author, year | Design | Vaccination status£* | Vaccine strain | Number of HI titre intervals$ | Drop-out rate# | ||
|---|---|---|---|---|---|---|---|
Vaccinated | Unvaccinated | Unknown | |||||
Bell et al., 1957 [32] | Challenge | 32 (14) | - | A | 3 | > 10% | |
Clark et al., 1983a [33] | Challenge | 49 (7) | 23 (16) | A | 6 | ≤ 10% | |
Clark et al., 1983b [34] | Challenge | 39 (6) | 58 (23) | A | 5 | ≤ 10% | |
Dowdle et al., 1973 [35] | Trial | 227 (90) | A | 4 | ≤ 10% | ||
Eaton and Meiklejohn, 1945 [36] | Trial | 94 (4) | 145 (9) | A(Olson) | 5 | ≤ 10% | |
94 (9) | 145 (4) | A(PR8) | |||||
94 (9) | 145 (4) | B | |||||
Evans, 1975 [37] | Cohort | 696 (262) | - | A | 5 | NA | |
346 (47) | B | ||||||
Farnik and Bruj, 1966 [38] | Cohort | - | 248 (52) | A | 5 | ≤ 10% | |
Fox et al., 1982 [39] | Cohort | - | - | 222 (13) | A(H1N1) | 4 | ≤ 10% |
343 (98) | A(H3N2) | 3 | |||||
140 (28) | B | 3 | |||||
Goodeve et al., 1983 [40] | Challenge | 97 (9) | 23 (15) | B | 6 | ≤ 10% | |
Greenberg, Couch and Kasel, 1974 [41] | Cohort | - | 212 (97) | A | 5 | ≤ 10% | |
Hirota et al., 1997 [24] | Trial | 84 (4) | 118 (9) | A(H1N1) | 3 | ≤ 10% | |
84 (4) | 118 (9) | A(H3N2) | |||||
84 (4) | 118 (9) | B | |||||
Hobson et al., 1972 [5] | Challenge | 106 (20) | A(Field Trial) | 9 | NA | ||
345 (166) | A(HK Salisbury) | ||||||
- | - | 119 (62) | A(Pre-1968) | ||||
462 (135) | B | ||||||
Meiklejohn et al., 1952 [42] | Trial | - | 101 (5) | A | 6 | > 10% | |
Potter et al., 1977 [43] | Challenge | 134 (26) | - | A | 6 | ≤ 10% | |
Salk et al., 1945 [8] | Trial | 82 (2) | 246 (21) | A(Weiss) | 10 | > 10% | |
82 (2) | 144 (12) | A(PR8) | |||||