Skip to main content

Table 3 Reviews where the most precise trial was statistically significant but the meta-analysis was not, with the p-value and effect estimates* of both.

From: Can we rely on the best trial? A comparison of individual trials and systematic reviews

Title of review Outcome measure Number of trials P value of meta analysis vs most precise trial (trial weight) Estimate of effect for meta analysis vs most precise trial I2
Prophylactic antibiotics for preventing early central venous catheter Gram positive infections in oncology patients Catheter related sepsis 4 0.06 vs <0.04 (51%) OR 0.55 vs 0.35 54%
Azithromycin for acute lower respiratory tract infections Clinical failure 14 0.9 vs < 0.001 (14%) RR 0.96 vs 0.52 58%
Directly observed therapy for treating tuberculosis Cure 4 0.1 vs < 0.006 (60%) 1.06 vs 1.13 64%
Laparoscopic colposuspension for urinary incontinence in women Number subjectively cured within 18 months 3 0.9 vs < 0.025 (56%) RR 1.0 vs 1.05 73%
Treatment of infantile spasms Cessation of spasms 2 0.1 vs < 0.02 (65%) OR 2.57 vs 1.35 69%
  1. * OR is the Odds Ratio; RR is the Relative Risk; I2 is the heterogeneity proportion