Semi-parametric risk prediction models for recurrent cardiovascular events in the LIPID study

Table 4 Different effect model of the recurrent MI events in the LIPID study

Risk factor	First MI event			Second MI event			Wald test^†
	HR	95% CI	P-value	HR	95% CI	P-value
Age (year)	1.02	1.01 - 1.03	<0.001	1.04	1.01 - 1.06	0.007	0.14
Smoking status
Non-smoker	1.0			1.0
Current smoker	1.49	1.20 - 1.85	<0.001	1.71	0.94 - 3.12	0.079	0.63
Total cholesterol	1.18	1.08 - 1.28	<0.001	1.34	1.08 - 1.66	0.007	0.21
HDL cholesterol	0.41	0.29 - 0.59	<0.001	0.17	0.06 - 0.47	0.001	0.076
Qualifying event for ACS
Unstable angina	1.0			1.0
Single MI	1.27	1.06 - 1.53	0.011	1.44	0.81 - 2.54	0.21	0.66
Multiple MI	1.92	1.54 - 2.40	<0.001	2.46	1.34 - 4.54	0.004	0.39
Revascularization
Never	1.0			1.0
Before ACS	1.54	1.23 - 1.92	<0.001	2.02	1.10 - 3.74	0.024	0.34
Since ACS	0.70	0.58 - 0.85	<0.001	0.65	0.36 - 1.16	0.14	0.76
History of stroke
No	1.0			1.0
Yes	1.50	1.12 - 2.00	0.006	1.31	0.57 - 3.04	0.53	0.75
Diabetes mellitus
No	1.0			1.0
Yes	1.40	1.12 - 1.75	0.003	1.14	0.58 - 2.23	0.70	0.53
Angina grade
CCVS < III	1.0			1.0
CCVS ≥ III	1.44	1.16 - 1.80	0.001	1.48	0.83 - 2.65	0.18	0.91
Treatment
Placebo	1.0			1.0
Pravastatin	0.72	0.62 - 0.83	<0.001	0.66	0.43 - 0.99	0.047	0.67

† P-value for Wald test. ACS = Acute Coronary Syndrome; CCVS = Canadian Cardiovascular Society Class of angina; HDL = High Density Lipoprotein; MI = Myocardial Infarction.

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