Semi-parametric risk prediction models for recurrent cardiovascular events in the LIPID study

Table 5 First event model of the recurrent MI events in the LIPID study

Risk factor	Hazard ratio	95% CI	P-value
Age (year)	1.02	1.01 - 1.03	<0.001
Smoking status
Non-smoker	1.0
Current smoker	1.49	1.20 - 1.86	<0.001
Total cholesterol	1.18	1.08 - 1.29	<0.001
HDL cholesterol	0.41	0.29 - 0.58	<0.001
Qualifying event for ACS
Unstable angina	1.0
Single MI	1.27	1.06 - 1.53	0.008
Multiple MI	1.92	1.55 - 2.39	<0.001
Revascularization
Never	1.0
Before ACS	1.54	1.24 - 1.90	<0.001
Since ACS	0.70	0.58 - 0.85	<0.001
History of stroke
No	1.0
Yes	1.50	1.12 - 2.00	0.007
Diabetes mellitus
No	1.0
Yes	1.40	1.12 - 1.74	0.003
Angina grade
CCVS < III	1.0
CCVS ≥ III	1.44	1.16 - 1.80	0.001
Treatment
Placebo	1.0
Pravastatin	0.72	0.62 - 0.83	<0.001

ACS = Acute Coronary Syndrome; CCVS = Canadian Cardiovascular Society Class of angina; HDL = High Density Lipoprotein; MI = Myocardial Infarction.

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