From: Estimates of sensitivity and specificity can be biased when reporting the results of the second test in a screening trial conducted in series
Observed Disease Status
+
-
Test 2
p D TP(2)
(1 - pD)FP(2)
p D p E FN(2)
p D (1 - p E )FN(2)+(1 - p D )TN(2)