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Table 5 Observed disease status and Test 2 results in a test if negative trial design

From: Estimates of sensitivity and specificity can be biased when reporting the results of the second test in a screening trial conducted in series

Test 2 Observed Disease Status Probability
+ + p D [FN(1) - FN(1, 2)]/Q
+ - (1 - p D )FP(2)/Q
- + p D p E FN(1,2)/Q
- - [(1 - p D )TN(2) + p D (1 - p E )FN(1, 2)/Q