Table 2 Replication strategies to achieve a desired TRP (α = 0.05, π = 0.015, q = 0.20).
Number of studies | Sample size per study/Total | Power per study | Final TRP after k studies |
|---|---|---|---|
2 | 860/1720 | 0.81 | 0.80 |
420/840 | 0.50 | 0.60 | |
3 | 260/780 | 0.32 | 0.80 |
420/1260 | 0.50 | 0.95 | |
4 | 140/560 | 0.20 | 0.80 |