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Table 2 Estimation of the final occurrence rate of the event P(E) at the end of follow-up according to the estimation method in MCAR and MAR scenarios (500 replications of samples sized 2000)

From: Multiple imputation for estimation of an occurrence rate in cohorts with attrition and discrete follow-up time points: a simulation study

  Scenario n° True occurrence rate of the event P(E)(%) Kaplan-Meier Multiple Imputation
    Estimate (a) Standard Error (a) Bias (b) Coverage (c) Estimate (a) Standard Error (a) Bias (b) Coverage (c)
MCAR scenarios 1 34.4 34.3 1.1 -0.04 94.6 34.4 1.2 -0.01 94.6
  2 61.3 61.3 1.2 -0.09 95.6 61.3 1.2 -0.08 95.0
  3 80.4 80.5 1.0 0.08 95.8 80.5 1.0 0.09 95.4
MAR scenarios 4 34.4 34.3 1.5 -0.07 95.2 34.4 1.8 0.01 94.4
  5 61.3 56.3 1.6 -5.1 10.6 61.5 1.8 0.2 92.4
  6 80.4 75.7 1.2 -4.7 2.6 80.6 1.1 0.2 92.2
  7 61.3 66.2 1.6 4.9 14.8 63.0 1.8 1.6 85.2
  8 80.4 87.4 1.5 7.0 0.2 82.1 1.8 1.7 83.4
  1. (a) mean value of the estimate and of the standard error of the 500 replications
  2. (b) difference between estimate and the true occurrence rate P(E)
  3. (c) proportion of 500 simulations-runs where the 95% Confidence Interval contained the true occurrence rate