Table 7 Group 2 (Investigators) (n = 24) - Testing performed at each Laboratory

Subjects at laboratory

24

24

24

24

24

23

14

12

CORE STUDIES

Daily diary

24

24

24

24

24

23

14

5

CPX Ramp (+muscle and brain NIRS)[17]

24

24

22

24

23

22

14

5

CPX ME

24

24

23

n/a

24

23

14

n/a

Spirometry

24

24

24

23

23

23

14

6

Venesection

24

24

24

24

24

23

14

n/a

Neurocognitive

21

21 (on return)

21

21

21

n/a

13

6

Pupillometry

24

24

24

20

24

23

14

0

Cranial measurement

24

n/a

n/a

n/a

n/a

n/a

n/a

n/a

Retinal Photography

24

n/a

n/a

n/a

24

23

n/a

n/a

Plasma biomarkers

24

24

24

24

24

23

n/a

n/a

ADDITIONAL STUDIES

Arterial Blood Gases[25]

10

n/a

n/a

n/a

9

n/a

9

n/a

Gastric Tonometry

10

n/a

n/a

n/a

n/a

9

n/a

n/a

Cardiac Output

10

n/a

n/a

n/a

n/a

9

n/a

n/a

Microcirculation[24]

24

n/a

24

n/a

24

23

14

4

Weight & Body comp

24

24

24

24

24

23

13

n/a

Muscle Biopsy

20

n/a

n/a

n/a

n/a

18

n/a

n/a

ECG

19

19

19

19

19

19

n/a

n/a

Oxygen circuit

n/a

n/a

n/a

n/a

n/a

n/a

5

n/a

Smell and taste

24

n/a

n/a

n/a

n/a

24

n/a

n/a

Thromboelastography

17

n/a

n/a

17

n/a

14

n/a

n/a

Cerebral Doppler

24

24

24

24

24

24

13

5

Saccadometry

22

22

22

22

22

22

12

n/a

Cardiac MRI and 31P-MRS

2

n/a

n/a

n/a

n/a

n/a

n/a

n/a

Skeletal Muscle MRI and 31P-MRS

7

n/a

n/a

n/a

n/a

n/a

n/a

n/a

MR Brain structural and volumetric studies

15

n/a

n/a

n/a

n/a

n/a

n/a

n/a