| Sequence generation | Allocation concealment | Blinding | Sample size calculation | Incomplete outecome | Intention-to-treat analysis | Free of selective reporting |
---|---|---|---|---|---|---|---|
 | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) |
Center | |||||||
Single-center | 20(64%) | 14(45%) | 13(42%) | 21(68%) | 17(55%) | 17(55%) | 21(68%) |
   (n = 31) |  |  |  |  |  |  |  |
Multi-center | 61(80%) | 48(63%) | 49(64%) | 62(82%) | 35(46%) | 57(75%) | 36(47%) |
   (n = 76) |  |  |  |  |  |  |  |
P value | 0.08 | 0.09 | 0.03 | 0.12 | 0.41 | 0.04 | 0.06 |
Funding source | |||||||
   Industry | 37(86%) | 31(72%) | 30(70%) | 34(80%) | 18(42%) | 28(65%) | 21(49%) |
   (n = 43) |  |  |  |  |  |  |  |
   Public | 28(70%) | 20(50%) | 19(48%) | 30(75%) | 23(58%) | 28(72%) | 25(63%) |
   (n = 40) |  |  |  |  |  |  |  |
P value | 0.07 | 0.04 | 0.04 | 0.66 | 0.16 | 0.64 | 0.21 |