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Table 1 Description of the observed and the simulated data sets for breast cancer and malignant melanoma patients

From: Imputation of missing values of tumour stage in population-based cancer registration

   Breast cancer data set Malignant melanoma data set
   Observed Simulated* Observed Simulated*
Number of cases   21,428 17,162 5,520 1,685
Sex (in %) Female 100 100 45.8 45.1
  Male 0 0 54.2 54.9
Age Median
(1st and 3rd Quartile)
62.0
(53.0; 71.0)
61.0
(52.0; 69.0)
61.0
(45.0; 70.2)
59.0
(43.0; 68.0)
T-stage (in %) 1 47.3 49.2 36.9 36.9
  2 34.0 34.3 11.8 12.4
  3 5.5 5.1 8.0 7.6
  4 7.3 5.7 4.7 4.4
  Unknown 6.0 5.7 38.6 38.7
N-stage (in %) 0 53.4 55.1 29.5 32.5
  1 25.4 25.2 1.7 1.4
  2 6.1 5.9 0.6 0.4
  3 3.7 3.5 0.2 0.1
  Unknown 11.4 10.3 67.9 65.6
M-stage (in %) 0 77.9 80.8 31.0 33.5
  1 5.6 3.7 2.2 0.7
  Unknown 16.5 15.4 66.8 65.8
UICC-stage (in %) I 32.0 29.7 23.9 7.4
  II 33.2 30.0 3.3 0.7
  III 11.4 10.4 2.8 0.8
  IV 5.6 3.7 0.5 0.7
  Unknown 17.8 26.1 69.5 90.4
Survival time (days) Median
(1st and 3rd Quartile)
1279
(549; 2161)
1279
(580; 2130)
1552
(700; 2253)
1765
(975; 2557)
Censoring (in %) Censored 84.6 88.5 88.1 90.5
Year of diagnosis 2000 10.2 9.7 10.8 15.1
  2001 10.7 10.2 11.5 14.4
  2002 11.1 10.6 10.0 10.9
  2003 10.8 10.9 14.3 12.2
  2004 10.7 10.7 12.8 14.6
  2005 10.7 10.9 10.7 8.9
  2006 11.5 11.6 10.0 10.8
  2007 11.6 12.1 9.7 5.0
  2008 12.7 13.4 10.3 8.1
Grading (in %) 1 10.6 10.6 3.4 5.7
  2 54.2 53.7 0.3 0.2
  3 30.0 30.1 0.2 0.2
  4 0.2 0.1 < 0.1 0.1
  Unknown 5.0 5.5 96.1 93.8
Radiotherapy (in %) Yes 66.4 80.2 1.4 0.5
  no 17.8 15.3 52.2 64.5
  Unknown 15.8 4.5 46.4 35.0
Chemotherapy (in %) Yes 46.1 47.9 1.8 1.4
  No 37.4 36.7 51.8 63.9
  Unknown 16.6 15.5 46.5 34.8
Hormone therapy (in %) Yes 60.6 62.3 0.0 0.0
  No 19.1 18.1   
  Unknown 20.3 19.6   
Morphology (in %) Infiltrating duct carcinoma 69.0 70.6   
  Lobular carcinoma 12.3 11.9   
  Infiltrating duct and lobular carcinoma 7.4 7.9   
  Nodular melanoma    12.4 13.6
  Lentigo maligna melanoma    5.3 5.1
  Superficial spreading melanoma    41.4 48.4
  Others and NOS 10.5 9.6 41.0 32.8
Topography (in %) Central portion of breast 5.3 5.1   
  Upper-inner quadrant of breast 9.3 9.6   
  Lower-inner quadrant of breast 4.6 4.7   
  Upper-outer quadrant of breast 35.7 36.3   
  Lower-outer quadrant of breast 6.3 6.3   
  Axillary tail of breast 0.2 0.1   
  Overlapping lesion of breast 8.9 8.2   
  Trunc    32.2 35.9
  Extremity    46.7 50.1
  Head/Neck    13.5 11.3
  NOS 29.9 29.7 7.6 2.7
  1. * For T-, N-, M- and UICC-stage the mean frequencies of the five simulated data sets are provided. The other variables distributions are identical in all five data sets.