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Table 2 Summary of results reported in a systematic review of reviews2

From: Methodology in conducting a systematic review of systematic reviews of healthcare interventions

Review Tocolytic agent Birth >48 hrs (95% CI) Birth >7 days (95% CI) Birth >34 weeks (95% CI) Birth >37 weeks (95% CI)
King 1988 Betamimetics compared with placebo or no treatment 12 trials OR 0.59, (0.42-0.83) Significant - - 8 trials OR 0.71 (0.53-0.96) Significant
Coomarasamy et al 2002 Atosiban V placebo (2 trials) Atosiban V beta-agonist (4 trials) 2 trials RR 1.13, (1.02-1.26) Significant 4 trials RR 1.07 (0.98-1.17) Not significant - 3 trials RR 1.25 (1.09-1.44) Significant - -
Crowther et al 2002 Magnesium sulphate V placebo/no treatment or other tocolytic agent 11 trials RR 0.85, (0.58-1.25) Not significant - No difference reported No difference reported
King et al 2003 Calcium channel blockers V any other tocolytic agent - RR 0.76, (0.60-0.97) Significant RR 0.83, (0.69-0.99) Significant RR 0.95, (0.83-1.09) Not significant
Anotayanonth et al 2004 Betamimetics V Placebo 11 trials RR 0.63, (0.53-0.75) Significant 11 trials RR 0.78, (0.68-0.90) Significant - 11 trials RR 0.95, (0.88-1.03) Not significant
King et al 2005 COX inhibitor V Placebo COX inhibitor V any other tocolytic 2 trials RR 0.20, CI 0.03-1.28 4 trials RR 0.59, CI 0.34-1.02 2 trials RR 0.41, CI 0.10-1.66 - 3 trials RR 0.21, CI 0.07-0.62 3 trials RR 0.53, CI 0.31-0.94
Whitworth & Quenby 2008 Oral betamimetic V placebo - - - RR 1.07, (0.14-8.09) Not significant
  1. 2 Reprinted from the European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 142, Smith V, Devane D, Begley CM, Clarke M, Higgins S. A systematic review and quality assessment of systematic reviews of randomised trials of interventions for preventing and treating preterm birth. 3-11, Copyright (2009), with permission from Elsevier.