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Table 3 TTP and RR Thresholds Generated with Censoring set at 0.1

From: Stopping rules employing response rates, time to progression, and early progressive disease for phase II oncology trials

Response Time to Progression Study Size Stage 1 Drug Rejection Stage 2 Drug Acceptance Power Alpha Error ENnul
/PESnul
ENalt
/PESalt
r alt r nul ttp alt ttp nul n 1 n 2 r 1 epd r 1+r 2 ttp     
0.05 0.2 3 6 15 15 ≤ -1 ≥ 16 ≥ 5 ≥ 5.5 0.812 0.034 30/0 30/0
0.05 0.2 3 7 15 15 ≤ 0 ≥ 5 ≥ 5 ≥ 6.25 0.822 0.021 26.8/0.21 29.8/0.01
0.05 0.2 4 7 15 15 ≤ 0 ≥ 4 ≥ 5 ≥ 6.25 0.811 0.084 26.8/0.21 29.5/0.03
0.05 0.2 4 8 15 15 ≤ 0 ≥ 10 ≥ 5 ≥ 7.25 0.818 0.038 29.998/
0.0001
29.998/
0.0001
0.05 0.2 5 8 15 15 ≤ 0 ≥ 9 ≥ 5 ≥ 7.25 0.821 0.151 29.996/
0.0003
29.995/
0.0004
0.1 0.3 3 7 15 15 ≤ 2 ≥ 5 ≥ 7 ≥ 6 0.864 0.033 24.4/0.37 29.5/0.03
0.1 0.3 4 7 15 15 ≤ 2 ≥ 4 ≥ 7 ≥ 6 0.837 0.106 24.4/0.38 28.9/0.08
0.1 0.3 4 8 15 15 ≤ 1 ≥ 4 ≥ 7 ≥ 7 0.859 0.054 26.2/0.25 29.6/0.03