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Figure 1 | BMC Medical Research Methodology

Figure 1

From: Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index

Figure 1

Degree of dominance h is a function of the deviation in risk of disease of the heterozygote wtmt from the co-dominant model, in which the heterozygote is expected to lay exactly in the middle of the two homozygotes (a). Dominance deviation can be positive or negative (b), with the heterozygote closer to the risk-exposed homozygote mtmt (0 <h ≤ 1), or to the risk-protected homozygote wtwt (-1 ≤ h < 0). Over-dominance (c) arises when the risk of disease of the heterozygote is higher than that of the risk-exposed homozygote (h > 1), whereas under-dominance (d) arises when the risk of disease of the heterozygote is lower than that of the risk-protected homozygote (h < -1).

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BMC Medical Research Methodology

ISSN: 1471-2288

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