Autism spectrum disorders and fetal hypoxia in a population-based cohort: Accounting for missing exposures via Estimation-Maximization algorithm

Table 4 Association of Fetal Hypoxia at Birth1 and Diagnosis of Autism Spectrum Disorders2: Results of Logistic Regression Fitted with EM Algorithm for Handling Unknown Exposures That are Modeled From Maternal and Birth Characteristics Under Specific NMAR Assumption Among Full-Term Male Births

Deviation from MAR³	Strong	Strong	Moderate	Weak
r	0.1	0.2	0.5	0.7
Odds ratio estimate	1.28	1.28	1.24	1.20
95% confidence interval	1.03, 1.60	1.03, 1.58	1.01, 1.52	0.99, 1.46
P-value	0.03	0.03	0.04	0.06

1: at least one of the three tests for fetal hypoxia is positive, i.e. fetal scalp pH < 7.25, or umbilical artery pH < 7.20, or venous pH < 7.28
2: singletons born in Alberta 1998-2004 and followed up till March 31, 2008, effects adjusted for birth year and socio-economic status
3: contribution of clinical judgment to prescribing the test beyond Z; MAR = missing at random, r = 1, see Table 3

ISSN: 1471-2288