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Table 7 Comparison of mean hazard ratios from the Branson & Whitehead method and ITT and PP approaches

From: Assessing methods for dealing with treatment switching in randomised controlled trials: a simulation study

Scenario Method Mean HR Bias Mean SE
2 ITT 0.7346 0.0346 0.0734
(×1.2 'Good' prognosis survival, 10% and 25% switching probabilities) PP - Exclude switchers 0.7071 0.0071 0.0746
  Branson and Whitehead 0.7077 0.0077 0.0708
6 ITT 0.8030 0.1030 0.0808
(×1.2 'Good' prognosis survival, 50% and 75% switching probabilities) PP - Exclude switchers 0.7153 0.0153 0.1004
  Branson and Whitehead 0.7172 0.0172 0.0724
10 ITT 0.7411 0.0411 0.0763
(×3 'Good' prognosis survival, 10% and 25% switching probabilities) PP - Exclude switchers 0.7280 0.0280 0.0793
  Branson and Whitehead 0.7165 0.0165 0.0738
14 ITT 0.8121 0.1121 0.0843
(×3 'Good' prognosis survival, 50% and 75% switching probabilities) PP - Exclude switchers 0.7810 0.0810 0.1142
  Branson and Whitehead 0.7325 0.0325 0.0762