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Table 7 Comparison of mean hazard ratios from the Branson & Whitehead method and ITT and PP approaches

From: Assessing methods for dealing with treatment switching in randomised controlled trials: a simulation study

Scenario

Method

Mean HR

Bias

Mean SE

2

ITT

0.7346

0.0346

0.0734

(×1.2 'Good' prognosis survival, 10% and 25% switching probabilities)

PP - Exclude switchers

0.7071

0.0071

0.0746

 

Branson and Whitehead

0.7077

0.0077

0.0708

6

ITT

0.8030

0.1030

0.0808

(×1.2 'Good' prognosis survival, 50% and 75% switching probabilities)

PP - Exclude switchers

0.7153

0.0153

0.1004

 

Branson and Whitehead

0.7172

0.0172

0.0724

10

ITT

0.7411

0.0411

0.0763

(×3 'Good' prognosis survival, 10% and 25% switching probabilities)

PP - Exclude switchers

0.7280

0.0280

0.0793

 

Branson and Whitehead

0.7165

0.0165

0.0738

14

ITT

0.8121

0.1121

0.0843

(×3 'Good' prognosis survival, 50% and 75% switching probabilities)

PP - Exclude switchers

0.7810

0.0810

0.1142

 

Branson and Whitehead

0.7325

0.0325

0.0762