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Table 2 Estimates of treatment effects for MS clinical trials in Japan

From: Alternative statistical methods for estimating efficacy of interferon beta-1b for multiple sclerosis clinical trials

Models

Parameter Estimates

Standard Error

Hazard Ratio [95%CI]

P value

1: Time-to-first-event Cox regression

-0.263

0.194

0.769 [0.526, 1.123]

0.174

2: AG model

-0.377

0.170

0.686 [0.492, 0.957]

0.027

3-1: PWP-T model

-0.268

0.132

0.765 [0.591, 0.989]

0.041

3-2: PWP-G model

-0.306

0.135

0.736 [0.565, 0.960]

0.024

4: WLW model

-0.489

0.231

0.613 [0.390, 0.965]

0.035

5: LWA model

-0.427

0.195

0.653 [0.445, 0.957]

0.029

6: Poisson regression model

-0.371

0.171

0.690 [0.493, 0.965]

0.030

7: GEE-Poisson model

-0.352

0.169

0.703 [0.505, 0.980]

0.037