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Table 3 Thresholds by DESR to compare with rules of Gehan (r alt = 0.2, r nu l = 0.05, epd alt = 0.3, epd nul = 0.5, power = 0.8, alpha = 0.05)

From: A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials

Study Size Stage 1 Drug Rejection Stage 2 Drug Acceptance Power Alpha Error ENnul/PESnul ENalt/PESalt
n 1 n 2 n 1r n 1p n 1r+n 2r n 1p+n 2p     
14 1 ≤1/14 ≥6/14 ≥2/17 ≤5/17 0.811 0.075 14.1/0.91 14.8/0.17
14 3 ≤1/14 ≥6/14 ≥3/17 ≤7/17 0. 773 0.043 14.3/0.91 16.5/0.17
14 4 ≤1/14 ≥6/14 ≥3/18 ≤7/18 0.775 0.038 14.3/0.91 17.3/0.17
14 5 ≤1/14 ≥6/14 ≥3/19 ≤7/19 0.773 0.034 14.4/0.92 18.2/0.17
14 6 ≤1/14 ≥6/14 ≥3/20 ≤7/20 0.769 0.031 14.5/0.91 19.0/0.17
14 9 ≤1/14 ≥6/14 ≥3/23 ≤9/23 0.805 0.038 14.8/0.91 21.5/0.17
14 10 ≤1/14 ≥6/14 ≥4/24 ≤9/24 0.753 0.026 14.9/0.91 22.3/0.17
14 11 ≤1/14 ≥6/14 ≥3/25 ≤9/25 0.797 0.033 14.9/0.91 23.2/0.17
14 13 ≤1/14 ≥6/14 ≥4/27 ≤11/27 0.791 0.023 15.1/0.91 24.8/0.17
14 15 ≤1/14 ≥6/14 ≥4/29 ≤11/29 0.789 0.024 15.3/0.91 26.5/0.17
14 16 ≤1/14 ≥6/14 ≥4/30 ≤11/30 0.787 0.028 15.4/0.91 27.3/0.17
14 18 ≤1/14 ≥6/14 ≥4/32 ≤13/32 0.811 0.023 15.5/0.91 29.0/0.17
14 20 ≤1/14 ≥6/14 ≥5/34 ≤13/34 0.781 0.015 15.7/0.91 30.7/0.17
14 21 ≤1/14 ≥6/14 ≥5/35 ≤13/35 0.779 0.013 15.8/0.91 31.5/0.17
14 22 ≤1/14 ≥6/14 ≥5/36 ≤15/36 0.803 0.016 15.9/0.91 32.3/0.17
14 23 ≤1/14 ≥6/14 ≥5/37 ≤15/37 0.804 0.014 16.0/0.91 33.2/0.17
  1. ENnul = expected number of patients accrued if a drug meets the criteria of the null hypothesis
  2. ENalt = expected number of patients accrued if a drug meets the criteria of the alternate hypothesis
  3. PESnul = probability of stopping the trial after stage I if a drug meets the criteria of the null hypothesis
  4. PESalt = probability of stopping the trial after stage I if a drug meets the criteria of the alternate hypothesis