| Stage I (n = 15 unless indicated)a | Stage II* | Stage I Stop? | Drug Activity | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Trial | Res | Prog | Resp | Prog | Flem | DESR epd0.4/0.6 | DESR epd0.3/0.5 | Flem | DESR epd0.4/0.6 | DESR epd0.3/0.5 |
1 | 0 | 6 | Â | Â | Y | N | Y | N | P | N |
2 | 0 | 1 | Â | Â | Y | N | N | N | P | P |
3 | 0 | 10 | Â | Â | Y | Y | Y | N | N | N |
4 | 0 | 7 | Â | Â | Y | N | Y | N | P | N |
5 | 0 | 9 | Â | Â | Y | Y | Y | N | N | N |
6 | 0 | 14 | Â | Â | Y | Y | Y | N | N | N |
7 | 0/14 | 7/14 | Â | Â | Y | N | Y | N | P | N |
8 | 0 | 6 | Â | Â | Y | N | Y | N | P | N |
9 | 0 | 3 | Â | Â | Y | N | N | N | P | P |
10 | 0 | 12 | Â | Â | Y | Y | Y | N | N | N |
11 | 1 | 9 | Â | Â | N | Y | Y | ? | N | N |
12 | 7 | 6 | 13/30 | 13/30 | N | N | N | Y | Y | Y |
13 | 1 | 6 | 1/25 | 12/25 | N | N | Y | N | Y | N |
14 | 1 | 6 | 3/30 | 13/30 | N | N | Y | N | Y | N |
15 | 2 | 4 | 2/30 | 8/30 | N | N | N | N | Y | Y |
16 | 1 | 6 | 4/29 | 12/29 | N | N | Y | Y | Y | N |