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Table 4 Comparison of the DESR and Fleming for Early Stopping and Rejection of H nul

From: A comparison of a new multinomial stopping rule with stopping rules of fleming and gehan in single arm phase II cancer clinical trials

  Stage I (n = 15 unless indicated)a Stage II* Stage I Stop? Drug Activity
Trial Res Prog Resp Prog Flem DESR epd0.4/0.6 DESR epd0.3/0.5 Flem DESR epd0.4/0.6 DESR epd0.3/0.5
1 0 6    Y N Y N P N
2 0 1    Y N N N P P
3 0 10    Y Y Y N N N
4 0 7    Y N Y N P N
5 0 9    Y Y Y N N N
6 0 14    Y Y Y N N N
7 0/14 7/14    Y N Y N P N
8 0 6    Y N Y N P N
9 0 3    Y N N N P P
10 0 12    Y Y Y N N N
11 1 9    N Y Y ? N N
12 7 6 13/30 13/30 N N N Y Y Y
13 1 6 1/25 12/25 N N Y N Y N
14 1 6 3/30 13/30 N N Y N Y N
15 2 4 2/30 8/30 N N N N Y Y
16 1 6 4/29 12/29 N N Y Y Y N
  1. aActual trial results.
  2. DESR epd 0.4/0.6 = Dual Endpoint Stopping Rule epd alt = 0.4, epd nul = 0.6
  3. DESR epd 0.3/0.5 = Dual Endpoint Stopping Rule epd alt = 0.3, epd nul = 0.5
  4. Flem = result according to rules of Fleming
  5. Prog = Progression
  6. Res = Response
  7. Y, N, P = Yes, No, Possible