Scatter-plot of pair measurements: Figure 4A depicts the average of pre- and post-event IR values are shown on a horizontal axis and the values for absolute difference are on a vertical axis. The horizontal line in the middle is the mean difference between the pre- and post-event IR values, and the dotted lines are the 95% CI for the pre-post difference. Figure 4B uses the log-transformed IR values and reveals a lesser dependency. An outlier is marked. Values of Pearson's and Spearman's correlation coefficients are shown for all subjects and by subgroups with and without the outlier.