Table 1 Dose-escalation-methods and results of 198 single-agent dose-seeking phase I trials
From: What does a modified-Fibonacci dose-escalation actually correspond to?
Guidance for the number of patients enrolled by dose-levels | |||
|---|---|---|---|
Algorithm-based methods (such as 3 + 3) n (%) | Model-based methods (such as CRM) n (%) | ||
Guidance for the dose-escalation | Modified-Fibonacci sequence | 92 (46.4) | 0 (0) |
Fixed increment: <+33% | 28 (14.1) | 0 (0) | |
Fixed increment: >100% | 62 (1.3) | 1 (0) | |
PK-guided | 3 (1.5) | 1 (0) | |
Other | 7 (3.5) | 4 (2) | |