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Table 1 Dose-escalation-methods and results of 198 single-agent dose-seeking phase I trials

From: What does a modified-Fibonacci dose-escalation actually correspond to?

   Guidance for the number of patients enrolled by dose-levels
   Algorithm-based methods (such as 3 + 3) n (%) Model-based methods (such as CRM) n (%)
Guidance for the dose-escalation Modified-Fibonacci sequence 92 (46.4) 0 (0)
  Fixed increment: <+33% 28 (14.1) 0 (0)
  Fixed increment: >100% 62 (1.3) 1 (0)
  PK-guided 3 (1.5) 1 (0)
  Other 7 (3.5) 4 (2)