Table 3 Incremental ratios
From: What does a modified-Fibonacci dose-escalation actually correspond to?
Dose-levels | Incremental ratio in genuine Fibonacci sequence | Incremental ratio in Modified Fibonacci sequence | Incremental ratio of median dose in 81 phase I |
|---|---|---|---|
1 | - | - | - |
2 | 2.000 | 2.000 | 2.000 |
3 | 1.500 | 1.670 | 1.500 |
4 | 1.667 | 1.500 | 1.333 |
5 | 1.600 | 1.333 | 1.333 |
6 | 1.615 | 1.333 | 1.333 |
7 | 1.619 | 1.333 | 1.333 |
8 | 1.617 | 1.333 | 1.300 |
9 | 1.618 | 1.333 | 1.350 |
10 | 1.618 | 1.333 | 1.320 |
11 | 1.618 | 1.333 | 1.240 |
12 | 1.618 | 1.333 | 1.250 |
13 | 1.618 | 1.333 | - |