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Figure 1 | BMC Medical Research Methodology

Figure 1

From: Designing cost-efficient randomized trials by using flexible recruitment strategies

Figure 1

Plots of total costs (A) and sample size (B) as a function of the symptom severity threshold used for inclusion criteria. The vertical line indicates the optimum threshold for minimum total cost. The treatment sample size (solid line in B) decreases as the symptom severity threshold increases, whereas the screening size (dashed line in B) is curvilinear as a function of the symptom severity threshold

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