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Table 3 Performance of the different methods for conditional inference when second stage sample size was different from planned: average over the different scenarios

From: What inference for two-stage phase II trials?

Property

Method

Π= Π 0

Π= Π 0 + δ

Bias

Π ̂ m

0.038

0.004

 

Π ̂ g

0.053

0.010

 

Π ̂ u

0.084

0.010

 

Π ̂ c

−0.003

−0.002

 

Π ̂ p

0.000

0.000

 

Π ̂ k

0.057

−0.003

RMSE

Π ̂ m

0.057

0.059

 

Π ̂ g

0.068

0.056

 

Π ̂ u

0.086

0.054

 

Π ̂ c

0.060

0.065

 

Π ̂ p

0.061

0.064

 

Π ̂ k

0.062

0.057

Rejection probability

p n

0.100

0.931

 

p m

0.110

0.936

 

p u

0.110

0.936

 

p c

0.035

0.844

 

p k

0.107

0.933

Coverage probability

Naive exact

0.899

0.939

 

Stage-wise

0.890

0.957

 

Mid-p

0.852

0.941

 

Conditional exact

0.939

0.929

 

Conditional score

0.910

0.894

 

Conditional mid-p

0.913

0.903

 

Koyama–Chen

0.889

0.956