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Table 1 Proportion with sequelaes and disability weights for selected cancer sites and data sources

From: Estimating and validating disability-adjusted life years at the global level: a methodological framework for cancer

Sites/sequelae

Source of data

Proportion*

Disability weights

Remarks

Rectum

    

Stoma

Morris E et al [22]

13% among colorectal cancer survivors

0.211

Not all rectal cancer patients had treatment leading to stoma.

Victorian weights for stoma.

Larynx

    

Loss of speech

Eindhoven cancer registry

6%

0.20

Proportion receiving total laryngectomy.

Melanoma of Skin

    

- Disfigurement grade I

De Vries et al [14]

25%

0.016

Lesion was on the face & Breslow thickness ≤2 mm or on the leg and arm & Breslow thickness >2 mm. GBD weight for cleft lip treated.

- Disfigurement grade II

 

Male: 7%, Female: 3%

0.056

Lesion was on the face & Breslow thickness >2 mm. GBD weight for other skin disease

Breast

    

Mastectomy

European average [23]

45%

0.20

Provisional weights

Cervix uteri

    

- Primary infertility

Hysterectomy is the standard treatment for this cancer

<40 years: 100%

0.18

Standard treatment including hysterectomy.

- Secondary infertility

40-50 years: 100%

0.10

Provisional weights

Corpus uteri cancer

    

- Primary infertility

Hysterectomy is the standard treatment for this cancer

<40 years: 100%

0.18

Standard treatment including hysterectomy.

- Secondary infertility

40-50 years: 100%

0.10

Provisional weight

Ovary

    

- Primary infertility

Hysterectomy is the standard treatment for this cancer

<40 years: 100%

0.18

Standard treatment including hysterectomy.

- Secondary infertility

40-50 years: 100%

0.10

Provisional weight

Prostate

    

- Incontinence

Kvale R et al [15],

5%

0.157

 

- Impotence

Johansson et al [16]

10%

0.195

 

- Primary infertility

 

<40 years: 25%

0.18

Infertility due to prostatectomy. Impotence has a higher weight so we assumed only 15% had disability due to infertility

- Secondary infertility

 

40-60 years: 25%

0.10

Provisional weight

Testis

 

16%

  

- Primary infertility

Brydoy M et al [17]

<40 years: 34%

0.18

 

- Secondary infertility

 

40-60 years: 27%

0.10

Provisional weight

Bladder (therapy removes prostate)

    

- Incontinence

Fossa S et al [18]

5%

0.157

 

- Impotence

Hardt [19]

10%

0.195

 

- Primary infertility

 

<40 years: 16%

0.18

Infertility due to prostatectomy. Impotence has a higher weight so assumed only 15% had disability due to infertility

- Secondary infertility

 

40-60 years: 16%

0.10

Provisional weight

  1. Data source for weights: Dutch and Victorian burden of disease study and the Global Burden of Disease project [3, 5, 6].