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BMC Medical Research Methodology

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Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

  • Benjamin Kasenda1,
  • Erik B von Elm2, 3,
  • John You4, 5,
  • Anette Blümle3,
  • Yuki Tomonaga6,
  • Ramon Saccilotto1,
  • Alain Amstutz1,
  • Theresa Bengough2,
  • Jörg Meerpohl3,
  • Mihaela Stegert1,
  • Kari A O Tikkinen4, 7,
  • Ignacio Neumann4,
  • Alonso Carrasco-Labra4,
  • Markus Faulhaber4,
  • Sohail Mulla4,
  • Dominik Mertz4,
  • Elie A Akl4, 8,
  • Dirk Bassler9,
  • Jason W Busse4, 10,
  • Ignacio Ferreira-González11,
  • Francois Lamontagne12,
  • Alain Nordmann1,
  • Rachel Rosenthal13,
  • Stefan Schandelmaier14,
  • Xin Sun15,
  • Per O Vandvik16,
  • Bradley C Johnston17,
  • Martin A Walter18,
  • Bernard Burnand2,
  • Matthias Schwenkglenks6,
  • Heiner C Bucher1,
  • Gordon H Guyatt4 and
  • Matthias Briel1, 4Email author
Contributed equally
BMC Medical Research Methodology201212:131

Received: 23 July 2012

Accepted: 1 August 2012

Published: 28 August 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
23 Jul 2012 Submitted Original manuscript
31 Jul 2012 Author responded Author comments - Benjamin Kasenda
Resubmission - Version 2
31 Jul 2012 Submitted Manuscript version 2
1 Aug 2012 Editorially accepted
28 Aug 2012 Article published 10.1186/1471-2288-12-131

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

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Authors’ Affiliations

Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
Cochrane Switzerland, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland
German Cochrane Centre, Institute of Medical Biometry and Medical Informatics, University Medical Centre Freiburg, Freiburg, Germany
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Department of Medicine, McMaster University, Hamilton, Canada
Institute for Social and Preventive Medicine, Zurich, Switzerland
Department of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland
Departments of Medicine and Family Medicine, State University of New York at Buffalo, Buffalo, USA
Department of Neonatology and Center for Pediatric Clinical Studies, University Children’s Hospital Tübingen, Tübingen, Germany
Department of Anesthesia, McMaster University, Hamilton, Canada
Epidemiology Unit, Department of Cardiology, Vall d'Hebron Hospital and CIBER de Epidemiología y Salud Publica (CIBERESP), Barcelona, Spain
Centre de Recherche Clinique Étienne-Le Bel and Department of Medicine, Université de Sherbrooke, Sherbrooke, Canada
Department of Surgery, University Hospital Basel, Basel, Switzerland
Academy of Swiss Insurance Medicine, University Hospital Basel, Basel, Switzerland
Center for Health Research, Kaiser Permanente Northwest, Portland, USA
Norwegian Knowledge Centre for the Health Services, Oslo, Norway
Department of Anesthesia & Pain Medicine, The Hospital for Sick Children, Toronto, Canada
Department of Nuclear Medicine, University Hospital Bern, Bern, Switzerland