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Table 4 Power calculations for different prevalences of a single risk factor for trial discontinuation; RCT, randomized controlled trial; OR, odds ratio

From: Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

Prevalence (%) of risk factor

Completed RCTs

RCTs discontinued due to slow accrual

Study power (%) to detect OR = 2.0

10

18

65

20

33

88

30

46

95

40

57

96

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BMC Medical Research Methodology

ISSN: 1471-2288

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