Study design | Controlled clinical trial | Observational study | Systematic review |
---|---|---|---|
Quality Assessment Criteria | ·Randomization adequate? | ·Non-biased selection? | ·Report clear review question, state inclusion and exclusion criteria of primary studies? |
 | · Allocation concealment adequate? | ·High overall loss to follow-up or differential loss to follow-up? |  |
 | ·Groups similar at baseline? |  |  |
 |  | ·Outcomes pre-specified and defined? | ·Substantial effort to find relevant research? |
 | ·Eligibility criteria specified? |  |  |
 |  | ·Ascertainment techniques adequately described? | ·Adequate assessment of validity of included studies? |
 | ·Outcome assessors masked? |  |  |
 | ·Care provider masked? | ·Non-biased and adequate ascertainment methods? | ·Sufficient detail of individual studies presented? |
 | ·Patient masked? |  |  |
 | ·ITT-analysis? | ·Statistical analysis of potential confounders? |  |
 | ·Maintenance of comparable groups? |  | ·Primary studies summarized appropriately? |
 |  | ·Adequate duration of follow-up? |  |
 | ·Acceptable levels of crossovers, adherence, and contamination? |  |  |
 | ·Overall and between-group attrition acceptable? |  |  |