Statistical adjustment of genotyping error in a case–control study of childhood leukaemia

Table 3 Results of Correction Procedure on Hypothetical Datasets for Two Types of Misclassification (observed in SNPs A and B)

Misclassification applied to data			‘Recessive’ artificial SNP 1		‘Log additive’ artificial SNP 2
			OR	95% CI^a	OR	95% CI^a
None^b	Uncorrected	Aa	1.01	0.73, 1.41	1.30	0.94, 1.80
		aa	2.04	1.29, 3.21	1.67	1.03, 2.71
None	Corrected	Aa	1.01	0.73, 1.41	1.30	0.94, 1.80
		aa	2.04	1.29, 3.21	1.67	1.03, 2.71
SNP A-type	Uncorrected	Aa	1.07	0.77, 1.49	1.37	0.99, 1.91
		aa	1.82	1.17, 2.84	1.50	0.93, 2.40
	Corrected	Aa	1.03	0.73, 1.45	1.32	0.95, 1.85
		aa	2.11	1.29, 3.45	1.74	1.04, 2.91
SNP B-type	Uncorrected	Aa	1.49	1.06, 2.09	1.92	1.37, 2.68
		aa	1.66	1.08, 2.54	1.36	0.86, 2.15
	Corrected	Aa	1.01	0.70, 1.45	1.30	0.91, 1.85
		aa	1.99	1.21, 3.26	1.63	0.97, 2.75

OR = Odds ratio; CI = confidence interval; Aa = Heterozygous genotype; aa = Homozygous mutant genotype.
^a Confidence intervals based on Wald method for uncorrected estimates and percentile-based for corrected estimates.
^bFree of genotyping error.

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