Statistical adjustment of genotyping error in a case–control study of childhood leukaemia

Table 5 Results of Analysis of Genotype Associated with Risk of ALL: Uncorrected and Corrected Case–control Analyses

ID	Geno-type	n cases/controls (uncorrected)	Uncorrected OR	95% CI	Mean n controls (corrected)^a	Corrected OR	95% CI
		Max 276/420
A	AA	116/186	1.0	referent	186	1.0	referent
	Aa	129/184	1.16	0.83, 1.61	189	1.13	0.81, 1.57
	aa	30/41	1.19	0.70, 2.03	36	1.35	0.76, 2.39
B	AA	122/170	1.0	referent	151	1.0	referent
	Aa	119/154	1.13	0.80, 1.58	186	0.81	0.56, 1.56
	aa	31/52	0.82	0.49, 1.37	39	0.95	0.53, 1.70
C	AA	87/119	1.0	referent	116	1.0	referent
	Aa	122/193	0.85	0.59, 1.23	208	0.76	0.52, 1.10
	aa	64/82	1.05	0.68, 1.63	71	1.16	0.73, 1.83
D	AA	174/262	1.0	referent	259	1.0	referent
	Aa	95/126	1.15	0.83, 1.61	136	1.04	0.74, 1.45
	aa	6/13	0.73	0.27, 1.97	6	1.74	0.44, 6.94
E	AA	62/78	1.0	referent	70	1.0	referent
	Aa	146/176	1.11	0.73, 1.68	205	0.84	0.54, 1.29
	aa	62/143	0.58	0.37, 0.92	122	0.59	0.37, 0.97
F	AA	204/315	1.0	referent	314	1.0	referent
	Aa	68/82	1.30	0.89, 1.89	83	1.26	0.87, 1.84
	aa	2/13	0.23	0.05, 1.06	13	0.23	0.05, 1.05

CI: Confidence interval; OR: odds ratio.
^a Mean number of controls with each genotype, after correction, based on one simulation of 50 iterations.

ISSN: 1471-2288