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Table 2 Model parameters for fixed and random effects two-dimensional (Weibull) network meta-analysis models with and without treatment-by-covariate interaction

From: Meta-regression models to address heterogeneity and inconsistency in network meta-analysis of survival outcomes

 

Fixed effects model

Random effects model (model 1)

Random effects model with treatment specific covariate interaction* (model 2)

Random effects model with constant treatment-by-covariate interaction* (model 3)

 

Median of posterior distribution

95% Credible Interval

Median of posterior distribution

95% Credible Interval

Median of posterior distribution

95% Credible Interval

Median of posterior distribution

95% Credible Interval

Pooled estimate for difference in scale β 0

 DTIC + IFN vs. DTIC (d 0AB )

−0.16

(−0.63; 0.33)

−0.22

(−0.76; 0.23)

−0.04

(−0.54; 0.47)

−0.18

(−0.58; 0.39)

 DTIC + non-IFN vs. DTIC (d 0AC )

−0.07

(−0.46; 0.34)

−0.19

(−0.65; 0.30)

−0.16

(−0.66; 0.32)

−0.10

(−0.51; 0.35)

 non-DTIC vs. DTIC (d 0AD )

−0.27

(−0.63; 0.13)

−0.30

(−0.88; 0.24)

−0.17

(−1.40; 1.11)

−0.43

(−1.12; 0.06)

Pooled estimate for difference in shape β 1

 DTIC + IFN vs. DTIC (d 1AB )

0.13

(−0.08; 0.33)

0.14

(−0.04; 0.34)

0.12

(−0.07; 0.30)

0.16

(−0.04; 0.30)

 DTIC + non-IFN vs. DTIC (d 1AC )

−0.06

(−0.23; 0.11)

−0.02

(−0.19; 0.15)

−0.04

(−0.21; 0.13)

−0.05

(−0.19; 0.10)

 non-DTIC vs. DTIC (d 1AD )

0.04

(−0.17; 0.23)

0.06

(−0.15; 0.27)

0.09

(−0.11; 0.29)

0.03

(−0.16; 0.21)

Estimate for covariate effect (βx)

 DTIC + IFN vs. DTIC (βx AB )

    

0.06

(−0.02; 0.16)

0.05

(−0.01; 0.12)

 DTIC + non-IFN vs. DTIC (βx AC )

    

0.06

(−0.05; 0.18)

0.05

(−0.01; 0.12)

 non-DTIC vs. DTIC (βx AD )

    

−0.02

(−0.21; 0.19)

0.05

(−0.01; 0.12)

Between study variance (heterogeneity) in scale

  

0.21

(0.02; 0.56)

0.19

(0.01; 0.52)

0.18

(0.01; 0.55)

  1. * Covariate value set at the average across studies.