| Fixed effects model | Random effects model (model 1) | Random effects model with treatment specific covariate interaction* (model 2) | Random effects model with constant treatment-by-covariate interaction* (model 3) | ||||
---|---|---|---|---|---|---|---|---|
 | Median of posterior distribution | 95% Credible Interval | Median of posterior distribution | 95% Credible Interval | Median of posterior distribution | 95% Credible Interval | Median of posterior distribution | 95% Credible Interval |
Pooled estimate for difference in scale β 0 | ||||||||
 DTIC + IFN vs. DTIC (d 0AB ) | −0.16 | (−0.63; 0.33) | −0.22 | (−0.76; 0.23) | −0.04 | (−0.54; 0.47) | −0.18 | (−0.58; 0.39) |
 DTIC + non-IFN vs. DTIC (d 0AC ) | −0.07 | (−0.46; 0.34) | −0.19 | (−0.65; 0.30) | −0.16 | (−0.66; 0.32) | −0.10 | (−0.51; 0.35) |
 non-DTIC vs. DTIC (d 0AD ) | −0.27 | (−0.63; 0.13) | −0.30 | (−0.88; 0.24) | −0.17 | (−1.40; 1.11) | −0.43 | (−1.12; 0.06) |
Pooled estimate for difference in shape β 1 | ||||||||
 DTIC + IFN vs. DTIC (d 1AB ) | 0.13 | (−0.08; 0.33) | 0.14 | (−0.04; 0.34) | 0.12 | (−0.07; 0.30) | 0.16 | (−0.04; 0.30) |
 DTIC + non-IFN vs. DTIC (d 1AC ) | −0.06 | (−0.23; 0.11) | −0.02 | (−0.19; 0.15) | −0.04 | (−0.21; 0.13) | −0.05 | (−0.19; 0.10) |
 non-DTIC vs. DTIC (d 1AD ) | 0.04 | (−0.17; 0.23) | 0.06 | (−0.15; 0.27) | 0.09 | (−0.11; 0.29) | 0.03 | (−0.16; 0.21) |
Estimate for covariate effect (βx) | ||||||||
 DTIC + IFN vs. DTIC (βx AB ) |  |  |  |  | 0.06 | (−0.02; 0.16) | 0.05 | (−0.01; 0.12) |
 DTIC + non-IFN vs. DTIC (βx AC ) |  |  |  |  | 0.06 | (−0.05; 0.18) | 0.05 | (−0.01; 0.12) |
 non-DTIC vs. DTIC (βx AD ) |  |  |  |  | −0.02 | (−0.21; 0.19) | 0.05 | (−0.01; 0.12) |
Between study variance (heterogeneity) in scale | Â | Â | 0.21 | (0.02; 0.56) | 0.19 | (0.01; 0.52) | 0.18 | (0.01; 0.55) |