Figure 1
From: A framework for organizing and selecting quantitative approaches for benefit-harm assessment
Key characteristics of the benefit-harm question that may guide selection of quantitative assessment for benefit-harm assessment. Abbreviations: INHB, Incremental net health benefit; MCE, Minimum clinical efficacy; NCB, Net Clinical Benefit; NNT, Number needed to treat; NNH, Number needed to treat for harm; Q-Twist, (Quality-adjusted) Time without Symptoms and Toxicity: RBC, Risk–benefit contour; RV-NNT, Relative value adjusted number needed to treat; QFRBA, Quantitative Framework for Risk and Benefit Assessment; TURBO, Transparent Uniform Risk Benefit; BLRA, Benefit-less-risk analysis; PSM, Probabilistic simulation methods; MERT, Minimum Target Event Risk for Treatment; MCDA, Multicriteria decision analysis: RBP, Risk–benefit plane; SPM, Stated preference method; MAR, Maximum acceptable risk.