Risk groups defined by Recursive Partitioning Analysis of patients with colorectal adenocarcinoma treated with colorectal resection

Table 1 Demographic and treatment of colorectal adenocarcinoma patients

	N	Cumulative survival (%) not died of cancer at 5-years	HR	95.0% CI	Significance*
Gender					0.000
male	5,937	69%	1.00
female	4,557	73%	0.86	0.80-0.93
AGE					0.000
> 50 yrs, < = 60 yrs	1,994	76%	1.00
< 50 yrs	1,516	75%	1.19	1.03-1.38
> 60 yrs, < = 70 yrs	2,811	73%	1.14	1.01-1.30
> 70 yrs	4,173	64%	1.64	1.46-1.84
Co-morbidity (CCI)					0.000
CCI = 0+1	952	87%	1.00
CCI = 2	4,033	78%	1.51	1.24-1.85
CCI > = 3	5,509	62%	1.92	1.58-2.33
Tumor location					0.000
rectum	3,967	70%	1.00
sigmoid colon	3,115	72%	0.84	0.77-0.93
colon (except sigmoid colon)	3,230	70%	1.02	0.93-1.13
overlapping or unspecified	182	61%	1.17	0.90-1.53
Number of lymph node examined					0.013
< 12	3,850	70%	1.00
> = 12	6,644	72%	0.91	0.84-0.98
Surgical margin					0.000
< = 2 mm	657	57%	1.00
> 2 mm, < = 1 cm	3,382	69%	0.57	0.49-0.66
> 1 cm	5,816	75%	0.47	0.41-0.54
Depth of tumor invasion					0.000
submucosa	958	89%	1.00
muscularis propria	1,613	82%	1.26	0.73-2.18
through the muscularis propria into the subserosa	6,315	68%	1.77	1.06-2.95
directly invades other organs or structures	1,608	58%	2.76	1.62-4.70
Tumor size					0.001
0-2 cm	625	79%	1.00
> 2.0, < = 3 cm	1,323	75%	0.82	0.66-1.02
> 3.0, < = 4 cm	2,067	72%	0.81	0.66-1.00
> 4.0, < = 6 cm	3,889	69%	0.82	0.67-1.01
> 6.0 cm	2,590	66%	0.98	0.80-1.21
Pathology
adenocarcinoma	10,016	71.6%	1.00		0.000
mucinous or signet ring cell adenocarcinoma	478	62.9%	1.50	1.27-1.76
TNM stage					0.000
stage I	2,114	88%	1.00
stage II	4,002	76%	1.23	0.96-1.58
stage III	4,378	56%	3.05	2.39-3.89
Radiotherapy					0.004
no	9,367	71%	1.00
yes	1,127	67%	1.21	1.07-1.38
Chemotherapy					0.000
no	5,385	68%	1.00
yes	5,109	73%	0.67	0.62-0.73

N: number; HR: hazard ratio; CI: confidence interval; CCI: Charlson comorbidity index; classification of TNM stage based on AJCC edition 6; *: log-rank P value

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