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Table 9 One-stage IPD meta-analyses investigating a non-proportional treatment effect

From: Individual patient data meta-analysis of survival data using Poisson regression models

Framework Covariate Poisson (1) Poisson (0.5) Poisson (0.25)
   Hazard Ratio 95% CI Hazard Ratio 95% CI Hazard Ratio 95% CI
Classical Treatment when t < 1, exp ( β ^ 1 ) 0.657 0.515 0.839 0.657 0.515 0.838 0.657 0.515 0.838
  Treatment when t ≥ 1, exp ( β ^ 1 + ϕ ^ ) 0.935 0.837 1.045 0.936 0.838 1.045 0.936 0.838 1.045
Bayesian Treatment when t < 1, exp ( β ^ 1 ) 0.657 0.521 0.839 0.656 0.508 0.837 0.657 0.521 0.845
  Treatment when t ≥ 1, exp ( β ^ 1 + ϕ ^ ) 0.934 0.833 1.049 0.936 0.841 1.045 0.935 0.835 1.042