TY - JOUR AU - Liquet, Benoit AU - Timsit, Jean-François AU - Rondeau, Virginie PY - 2012 DA - 2012/06/15 TI - Investigating hospital heterogeneity with a multi-state frailty model: application to nosocomial pneumonia disease in intensive care units JO - BMC Medical Research Methodology SP - 79 VL - 12 IS - 1 AB - Multistate models have become increasingly useful to study the evolution of a patient’s state over time in intensive care units ICU (e.g. admission, infections, alive discharge or death in ICU). In addition, in critically-ill patients, data come from different ICUs, and because observations are clustered into groups (or units), the observed outcomes cannot be considered as independent. Thus a flexible multi-state model with random effects is needed to obtain valid outcome estimates. SN - 1471-2288 UR - https://doi.org/10.1186/1471-2288-12-79 DO - 10.1186/1471-2288-12-79 ID - Liquet2012 ER -