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Table 4 Reproducibility and accuracy results for the survival probabilities, the medians, the HRs and their uncertainties; ME: mean error; MAE: mean absolute error; σ r : standard deviation due to reproducibility; σ e : standard deviation due to exemplar

From: Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves

Survival probabilities
  ME (95%CI) MAE (95% CI) σ r (95% CI) σ e (95% CI)
All information -0.103% (-0.260; 0.055) 0.272% (0.021; 1.544) 0.270% (0.234; 0.577) 0.226% (0.138; 0.410)
No numbers at risk -0.051% (-0.186; 0.083) 0.279% (0.019; 1.321) 0.294% (0.253; 0.411) 0.205% (0.113; 0.383)
No total events 0.079% ( -0.111; 0.269) 0.358% (0.035; 2.504) 0.316% (0.283; 0.600) 0.396% (0.293; 0.579)
Neither 0.101% (-0.069;0.270) 0.328% (0.031; 2.233) 0.289% (0.259; 0.547) 0.373% (0.277; 0.547)
Medians
  ME (95%CI) MAE (95% CI) σ r (95% CI) σ e (95% CI)
All information 0.011 (0.004; 0.018) 0.011 (0.001; 0.036) 0.006 (0.004; 0.012) 0.005 (0.001; 0.037)
No numbers at risk 0.010 (0.005; 0.014) 0.010 (0.001; 0.027) 0.006 (0.005; 0.021) 0.002 (0.000; 0.021)
No total events 0.005 (-0.001; 0.012) 0.010 (0.001; 0.045) 0.011 (0.009; 0.015) 0.008 (0.003; 0.019)
Neither 0.004 (-0.001; 0.010) 0.011 (0.001; 0.045) 0.015 (0.012; 0.021) 0.005 (0.000; 0.016)
Hazard ratios
  ME (95%CI) MAE (95% CI) σ r (95% CI) σ e (95% CI)
All information 0.008 (-0.015; 0.030) 0.017 (0.002; 0.122) 0.021 (0.017; 0.041) 0.021 (0.009; 0.085)
No numbers at risk 0.007 (-0.036; 0.049) 0.036 (0.003; 0.242) 0.037 (0.028; 0.058) 0.041 (0.019; 0.164)
No total events 0.021 (-0.004; 0.045) 0.028 (0.002; 0.167) 0.018 (0.015; 0.029) 0.029 (0.017; 0.074)
Neither 0.037 (-0.190; 0.264) 0.198 (0.021; 1.556) 0.016 (0.013; 0.028) 0.284 (0.177; 0.699)
Standard errors of the log hazard ratios
  ME (95%CI) MAE (95% CI) σ r (95% CI) σ e (95% CI)
All information 0.002 (-0.035; 0.040) 0.021 (0.002; 0.149) 0.024 (0.017; 0.114) 0.023 (0.005; 0.764)
No numbers at risk -0.010 (-0.034; 0.014) 0.016 (0.001; 0.095) 0.016 (0.012; 0.060) 0.016 (0.002; 0.526)
No total events -0.022 (-0.057; 0.014) 0.033 (0.003; 0.204) 0.018 (0.014; 0.055) 0.035 (0.019; 0.133)
Neither -0.143 (-0.262; -0.023) 0.143 (0.010; 0.736) 0.039 (0.031; 0.100) 0.121 (0.067; 0.452)
  1. Note that the study 1 did not report the total number of events.
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BMC Medical Research Methodology

ISSN: 1471-2288

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