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Table 4 Reproducibility and accuracy results for the survival probabilities, the medians, the HRs and their uncertainties; ME: mean error; MAE: mean absolute error; σ r : standard deviation due to reproducibility; σ e : standard deviation due to exemplar

From: Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves

Survival probabilities

 

ME (95%CI)

MAE (95% CI)

σ r (95% CI)

σ e (95% CI)

All information

-0.103% (-0.260; 0.055)

0.272% (0.021; 1.544)

0.270% (0.234; 0.577)

0.226% (0.138; 0.410)

No numbers at risk

-0.051% (-0.186; 0.083)

0.279% (0.019; 1.321)

0.294% (0.253; 0.411)

0.205% (0.113; 0.383)

No total events

0.079% ( -0.111; 0.269)

0.358% (0.035; 2.504)

0.316% (0.283; 0.600)

0.396% (0.293; 0.579)

Neither

0.101% (-0.069;0.270)

0.328% (0.031; 2.233)

0.289% (0.259; 0.547)

0.373% (0.277; 0.547)

Medians

 

ME (95%CI)

MAE (95% CI)

σ r (95% CI)

σ e (95% CI)

All information

0.011 (0.004; 0.018)

0.011 (0.001; 0.036)

0.006 (0.004; 0.012)

0.005 (0.001; 0.037)

No numbers at risk

0.010 (0.005; 0.014)

0.010 (0.001; 0.027)

0.006 (0.005; 0.021)

0.002 (0.000; 0.021)

No total events

0.005 (-0.001; 0.012)

0.010 (0.001; 0.045)

0.011 (0.009; 0.015)

0.008 (0.003; 0.019)

Neither

0.004 (-0.001; 0.010)

0.011 (0.001; 0.045)

0.015 (0.012; 0.021)

0.005 (0.000; 0.016)

Hazard ratios

 

ME (95%CI)

MAE (95% CI)

σ r (95% CI)

σ e (95% CI)

All information

0.008 (-0.015; 0.030)

0.017 (0.002; 0.122)

0.021 (0.017; 0.041)

0.021 (0.009; 0.085)

No numbers at risk

0.007 (-0.036; 0.049)

0.036 (0.003; 0.242)

0.037 (0.028; 0.058)

0.041 (0.019; 0.164)

No total events

0.021 (-0.004; 0.045)

0.028 (0.002; 0.167)

0.018 (0.015; 0.029)

0.029 (0.017; 0.074)

Neither

0.037 (-0.190; 0.264)

0.198 (0.021; 1.556)

0.016 (0.013; 0.028)

0.284 (0.177; 0.699)

Standard errors of the log hazard ratios

 

ME (95%CI)

MAE (95% CI)

σ r (95% CI)

σ e (95% CI)

All information

0.002 (-0.035; 0.040)

0.021 (0.002; 0.149)

0.024 (0.017; 0.114)

0.023 (0.005; 0.764)

No numbers at risk

-0.010 (-0.034; 0.014)

0.016 (0.001; 0.095)

0.016 (0.012; 0.060)

0.016 (0.002; 0.526)

No total events

-0.022 (-0.057; 0.014)

0.033 (0.003; 0.204)

0.018 (0.014; 0.055)

0.035 (0.019; 0.133)

Neither

-0.143 (-0.262; -0.023)

0.143 (0.010; 0.736)

0.039 (0.031; 0.100)

0.121 (0.067; 0.452)

  1. Note that the study 1 did not report the total number of events.