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Table 1 Comparison of mortality reduction estimates using the standard and the proposed method

From: Beyond case fatality rate: using potential impact fraction to estimate the effect of increasing treatment uptake on mortality

Disease

Treatment

Original method

PIF-based method

Percentage difference in DPP

  

DPP

% mortality reduction

DPP

% mortality reduction

 

AMI

 

223.05

2.22

236.16

2.35

5.88

 

Beta blockers

7.13

0.07

7.29

0.07

2.24

 

ACE inhibitors

43.98

0.44

45.25

0.45

2.89

 

Reperfusion

164.78

1.64

179.59

2.04

8.99

 

Statins

7.16

0.07

8.29

0.08

15.78

2’ Prevention post AMI

 

176.82

1.76

178.50

1.77

0.95

 

Beta blockers

8.08

0.08

9.36

0.09

15.84

 

ACE inhibitors

31.83

0.32

35.12

0.35

10.34

 

Statins

2.58

0.03

2.98

0.03

15.50

 

Rehabilitation

134.33

1.34

138.11

1.37

2.81

ACS

 

21.26

0.21

22.66

0.23

6.59

 

Beta blockers

1.77

0.02

1.81

0.02

2.26

 

ACE inhibitors

9.56

0.10

9.82

0.10

2.72

 

Statins

9.93

0.10

11.29

0.11

13.70

Chronic angina and CHD: medical therapy

 

703.81

7.00

743.31

7.39

5.61

 

Aspirin

106.61

1.06

116.16

1.16

8.96

 

ACE inhibitors

436.83

4.34

463.12

4.60

6.02

 

Statins

160.37

1.59

182.27

1.81

13.66

Chronic angina and CHD: PCI

 

7.06

0.07

7.51

0.08

6.37

 

Aspirin

0.64

0.01

0.70

0.01

9.37

 

ACE inhibitors

5.70

0.06

6.06

0.06

6.32

 

Statins

0.72

0.01

0.83

0.01

15.28

Chronic angina and CHD- CABG

 

14.10

0.14

15.16

0.15

7.52

 

Aspirin

2.09

0.02

2.29

0.02

9.57

 

ACE inhibitors

10.33

0.10

11.11

0.11

7.55

 

Statins

1.68

0.02

1.94

0.02

15.48

Hospital heart failure

 

149.80

1.49

165.17

1.64

10.26

 

ACE inhibitors

47.00

0.47

51.46

0.51

9.49

 

Beta blockers

102.80

1.02

118.81

1.18

15.57

Community heart failure

 

601.33

5.98

686.99

6.83

14.25

 

ACE inhibitors

199.61

1.98

221.30

2.20

10.87

 

Beta blockers

401.72

3.99

480.61

4.78

19.64

Hypertension Treatment

 

60.25

0.60

62.10

0.62

3.07

 

all treatments

60.25

0.60

62.10

0.62

3.07

Hyperlipidemia Treatment

 

135.15

1.34

145.02

1.44

7.30

 

Statins 1’ prevention

135.15

1.34

145.02

1.44

7.30

Total

 

2092.63

20.80

2262.59

22.49

8.12

  1. Single treatment and treatment combination level data for deaths prevented or postponed, under the standard and the PIF-based method. ACE angiotensin-converting enzyme, ACS acute coronary syndrome, AMI acute myocardial infarction, ARB angiotension receptor blocker, CABG coronary artery bypass grafting, DPP deaths prevented or postponed, PCI percutaneous coronary intervention.