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Table 6 Three possible methods of averaging ratios between successive score values

From: The index ‘Treatment Duration Control’ for enabling randomized controlled trials with variation in duration of treatment of chronic pain patients

equal baseline scores:

 

S 1,i

ratio (R i )

S 2,i

log(R i )

C i = (R i -1)/(R i + 1)

50

2

100

0.301

0.333

50

1

50

0.000

0.000

50

0.5

25

0.301

-0.333

Method (1):

mean S 1,i  = 50.0

Method (2): mean of R i values: 1.17

mean S 2,i  = 58.3

(mean S 2,i )/(mean S 1,i ) = 1.17

Method (3):

mean of log(R i ) values: 0.000 ; mean R: 1.00

 

(re-transformed mean log-value:10(mean log(Ri))

mean of C i values: 0.000 ; mean R: 1.00

  

(re-transformed mean C-value: (1 + C)/(1-C))

non-equal baseline scores, largest baseline with smallest R i value:

 

S 1,i

ratio (R i )

S 2,i

log(R i )

C i = (R i -1)/(R i + 1)

 

20

2

40

0.301

0.333

40

1

40

0.000

0.000

60

0.5

30

-0.301

-0.333

Method (1):

mean S 1,i  = 40.0

Method (2): mean of R i values: 1.17

mean S 2,i  = 36.7

(mean S 2,i )/(mean S 1,i ) = 0.917

Method (3):

mean of log(R i ) values: 0.000 ; mean R: 1.00

 

(re-transformed mean log-value:10(mean log(Ri))

mean of C i values: 0.000 ; mean R: 1.00

  

(re-transformed mean C-value: (1 + C)/(1-C))

non-equal baseline scores, largest baseline with largest R i value:

 

S 1,i

ratio (R i )

S 2,i

log(R i )

C i = (R i -1)/(R i + 1)

 

20

0.5

10

0.301

0.333

40

1

40

0.000

0.000

60

2

120

-0.301

-0.333

Method (1):

mean S 1,i  = 40.0

Method (2): mean of R i values: 1.17

mean S 2,i  = 56.7

(mean S 2,i )/(mean S 1,i ) = 1.42

Method (3):

mean of log(R i ) values: 0.000 ; mean R: 1.00

 

(re-transformed mean log-value:10(mean log(Ri))

mean of C i values: 0.000 ; mean R: 1.00

  

(re-transformed mean C-value: (1 + C)/(1-C))

  1. S 1,i and S 2,i , subsequent score values of three items ( i = 1..3) at times ‘1’ and ‘2’ respectively. R i , ratio between S 2,i and S 1,i (multiplication factor of S 1,i ). log(R i ), logarithmically transformed R i -values. C i , R i -values transformed as Contrast-values. Three methods of averaging ratio values are illlustrated; Methods (3) includes two variants of data transformation, logarithmically and as Contrast. For further explanation, see text.