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Table 1 Variance partitioning of ultrasound measurements and patient characteristics

From: Screening for data clustering in multicenter studies: the residual intraclass correlation

Variable

n

Coefficient of variation/Prevalence

VPC

R2

RICC

Patient age (years)

2407

0.4

1.9%

13.9%

2.2%

[0.8% to 3.3%]

[10.6% to 17.4%]

[0.9% to 3.7%]

Number of locules (ordinal)

1997c

0.8

2.6%

10.6%

2.9%

[0.5% to 4.4%]

[6.7% to 14.2%]

[0.6% to 4.9%]

Maximum diameter of the solid component (mm, log transformed)

1160b

0.2

2.4%

22.4%

3.1%

[0.0% to 5.7%]

[17.4% to 28.9%]

[0.0% to 7.3%]

Serum CA125 (IU/L, log transformed)

1827a

0.4

2.0%

37.8%

3.3%

[0.8% to 4.3%]

[32.8% to 41.7%]

[1.3% to 6.8%]

Acoustic shadows (yes/no)

2407

13.7%

3.0%

14.2%

3.4%

[0.0% to 5.0%]

[8.0% to 72.1%]

[0.0% to 5.9%]

Number of papillations (ordinal)

468d

0.6

2.9%

15.7%

3.5%

[0.0% to 5.5%]

[13.6% to 23.8%]

[0.0% to 6.6%]

Maximum lesion diameter (mm, log transformed)

2406e

0.1

4.5%

9.2%

4.9%

[1.0% to 10.1%]

[5.9% to 11.4%]

[1.1% to 11.0%]

Presence of solid components (yes/no)

2407

48.2%

3.2%

43.5%

5.7%

[1.0% to 4.4%]

[39.8% to 73.5%]

[2.3% to 8.4%]

Bilateral (yes/no)

2407

16.6%

7.8%

6.1%

8.3%

[0.0% to 30.0%]

[3.6% to 8.2%]

[0.0% to 31.6%]

Ascites (yes/no)

2407

10.0%

4.9%

43.0%

8.5%

[0.0% to 9.5%]

[34.5% to 49.3%]

[0.0% to 15.8%]

Free fluid in pouch of Douglas (yes/no)

2407

25.4%.

8.3%

14.0%

9.6%

[2.2% to 13.3%]

[11.1% to 17.5%]

[2.6% to 15.2%]

Presence of papillations (yes/no)

2407

19.6%

8.7%

11%

9.8%

[3.7% to 12.9%]

[7.4% to 14.9%]

[4.1% to 14.8%]

Irregular internal wall (yes/no)

2407

38.5%

10.0%

13.8%

11.6%

[2.7% to 16.7%]

[11.6% to 16.7%]

[3.1% to 19.5%]

Peak systolic velocity (cm/s, log transformed)

1432g

0.3

11.2%

5.9%

11.9%

[5.3% to 16.3%]

[2.4% to 10.8%]

[6.0% to 16.9%]

Metastases (yes/no)

1457f

10.7%

5.3%

57.9%

12.6%

[0.2% to 8.4%]

[52.9% to 95.3%]

[1.3% to 21.1%]

Height of papillation (mm, log transformed)

468d

0.3

10.9%

16.7%

13.1%

[0.0% to 28.2%]

[6.3% to 25.5%]

[0.0% to 31.7%]

Resistance index

1432g

0.3

14.5%

8.4%

15.9%

[1.7% to 23.6%]

[4.6% to 13.5%]

[1.9% to 26.5%]

Papillations with detectable blood flow (yes/no)

468d

47.4%

11.3%

30.4%

16.2%

[2.8% to 17.1%]

[25.6% to 41.2%]

[4.4% to 23.8%]

Color score of intratumoral blood flow (ordinal)

2407

0.5

12.2%

30.9%

17.6%

[3.6% to 22.6%]

[24.9% to 36.3%]

[5.6% to 30.1%]

Pelvic pain during examination (yes/no)

2407

19.1%

18.6%

1.5%

18.9%

[6.6% to 26.5%]

[0.9% to 9.4%]

[9.8% to 27.1%]

Personal history of ovarian cancer (yes/no)

2407

1.6%

16.5%

13.1%

19.0%

[0.0% to 25.3%]

[10.3% to 72.8%]

[0.0% to 30.3%]

Current use of hormonal therapy (yes/no)

2407

12.7%

19.5%

2.6%

20.0%

[10.0% to 30.4%]

[1.3% to 9.0%]

[10.6% to 31.2%]

Amount of free fluid in pouch of Douglas (mm, log transformed)

616h

0.3

21.2%

15.5%

25.1%

[5.1% to 28.4%]

[9.8% to 21.7%]

[6.7% to 32.1%]

  1. Percentage of the total variance at the sonographer level (VPC) (% [90 CI]), percentage of the total variance explained by tumour type (R2) (% [90 CI]) and the residual intraclass correlation (RICC) (% [90 CI]). aMeasurement of CA125 was not obligatory; bIf at least one solid component is present; cIf there is at least one locul; dIn case of the presence of a papillary structure; eOne influential outlier removed (measurement error); fAssessment of presence of metastases was not obligatory; gIf there is intratumoural blood flow; hIf there is fluid in the pouch of Douglas.