Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach

Table 1 Simulation results of the association parameter, α

True	True	Weibull				Joint model
α	σ _e	Bias	% bias	MSE	CP	Bias	% bias	MSE	CP
	0.1	-0.001	-0.2	0.006	94.8	0.005	0.9	0.006	95.3
0.50	0.5	-0.105	-21.1	0.016	65.4	0.005	0.9	0.007	95.6
	1.0	-0.261	-52.1	0.071	0.4	0.008	1.6	0.012	94.8
	0.1	0.002	1.0	0.005	94.4	0.005	2.0	0.006	94.3
0.25	0.5	-0.046	-18.5	0.007	89.0	0.007	2.7	0.007	94.5
	1.0	-0.123	-49.2	0.018	34.1	0.010	4.1	0.009	94.8
	0.1	0.003	-1.3	0.006	93.8	0.001	-0.2	0.006	94.0
-0.25	0.5	0.051	-20.6	0.007	87.1	0.000	-0.1	0.007	94.2
	1.0	0.127	-50.7	0.019	29.7	-0.002	0.9	0.009	94.6
	0.1	0.000	-0.1	0.006	96.6	-0.005	1.0	0.006	95.9
-0.50	0.5	0.104	-20.9	0.015	66.7	-0.006	1.1	0.007	95.7
	1.0	0.260	-52.0	0.070	0.4	-0.010	2.0	0.012	94.5