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Table 1 Simulation results of the association parameter, α

From: Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach

True True Weibull Joint model
α σ e Bias % bias MSE CP Bias % bias MSE CP
  0.1 -0.001 -0.2 0.006 94.8 0.005 0.9 0.006 95.3
0.50 0.5 -0.105 -21.1 0.016 65.4 0.005 0.9 0.007 95.6
  1.0 -0.261 -52.1 0.071 0.4 0.008 1.6 0.012 94.8
  0.1 0.002 1.0 0.005 94.4 0.005 2.0 0.006 94.3
0.25 0.5 -0.046 -18.5 0.007 89.0 0.007 2.7 0.007 94.5
  1.0 -0.123 -49.2 0.018 34.1 0.010 4.1 0.009 94.8
  0.1 0.003 -1.3 0.006 93.8 0.001 -0.2 0.006 94.0
-0.25 0.5 0.051 -20.6 0.007 87.1 0.000 -0.1 0.007 94.2
  1.0 0.127 -50.7 0.019 29.7 -0.002 0.9 0.009 94.6
  0.1 0.000 -0.1 0.006 96.6 -0.005 1.0 0.006 95.9
-0.50 0.5 0.104 -20.9 0.015 66.7 -0.006 1.1 0.007 95.7
  1.0 0.260 -52.0 0.070 0.4 -0.010 2.0 0.012 94.5
  1. MSE - mean square error.
  2. CP - coverage probability.
  3. σ e - standard deviation of the measurement error.